My grandmother, 75 yrs of age, is a diabetic
for past 15-20 years, taking
metformin (2g daily) plus insulin (40+35). Where I am from we don't usually give a basal bolus regimen, just 70/30 in morning and evening. She also has history of IHD one year back.
Recently, her renal function tests revealed a creatinine of 2.0 (178micromole/L). Her GFR according to MDRD equation is less than 30. This clearly means metformin should be stopped.