Gleevec rems

Common Questions and Answers about Gleevec rems

gleevec

535089 tn?1400673519 FDAAA also authorizes FDA to require holders of certain drug applications approved without a REMS to submit a proposed REMS if the agency becomes aware of new safety information and makes a determination that a REMS is necessary to ensure the benefits of the drug outweigh its risks. Opioid drugs have benefit when used properly and are a necessary component of pain management for certain patients. Opioid drugs have serious risks when used improperly.
Avatar f tn Hi there, My doctor of 10 years recently closed his practice and referred me to see a new pain specialist. However, the new doctor is not registered with TIRF REMS to be able to prescribe Actiq that I have been taking for 9 years. I am post stage 3 breast cancer, double mastectomy, peripheral neuropathy and lymphedema to name a few of my issues not to mention I have tried every opiod on the market and I'm also opiod tolerant.
Avatar m tn Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count. This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
Avatar n tn Is it possible that after taking gleevec for only two weeks WBC droped from 36.7 to 7? All other blood counts are also came back to normal range. Could doctor make mistake in diagnosis of CML? Maybe I should get seg second opinion?
Avatar n tn I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
Avatar n tn After two weeks on 400mlg gleevec my WBC droped from 36.5 to 7.1. My doctor told to come for additional test in two weeks. Now my WBC is 1.3 and absolute neutrophils count is 0.04. I was told to stay home on antibiotics. How long it may take for my counts to clime back to safe range. And of course, I'm off gleevec right now. Does it seem that dose of 400mlg is too high for me.
Avatar n tn Am on Gleevec 400mg, now having problems with blisters on the palm. What can I do about it?
Avatar f tn I was diagnosed last year and was immediatley put on gleevec 400mg/day.At my last consult my metabolic stats had risen,hence blood tests to determine if the gleevec is no longer working.I am still in firstphase and wonder what my options are if the gleevec is no longer an option.Amin pretty good form,just very tired and a lot of bone pain.
Avatar m tn I have CML and was treated with Gleevec for 4 years and achieved remission. I have for the past several months been experiencing sudden onset of weakness which last for hours, to days. My blood pressure which has remained under control for several years with atenolol has been running 145/105 and higher for the past three to four months. I have a feeling of fullness in my stomach, and I have sporatic episodes of mild coughing, this occurs maybe once a week.
Avatar m tn As long as your getting your REMS which is usually 2 hrs into sleep you will wake up feeling refreshed. I sometimes get 2 hrs, 4 hrs..It's the Quality of sleep that matters not the quantity of sleep..
Avatar n tn You might find he starts to be able to tolerate the pill. Gleevec is first choice for treating CML, and if he is doing good in every other way then encourage him that he is doing great. I hope this helps you. I would be glad to help you with any other questions.
Avatar f tn Been through every test(mri, catscan, mra, ekg,eeg,emg, etc.) including a sleep test which said my REMs were normal, but I fell asleep in less then 3 minutes each time( during the nap phase) and had no idea how long I slept...so narcolepsy was ruled out. But they told me to take my regular sleep aide before I went to bed that night andthen was told it could have screwed up my REMS.
408795 tn?1324935675 Modified Risk Evaluation and Mitigation Strategies (REMS) for Nplate (romiplostim) and Promacta (eltrombopag The U.S. Food and Drug Administration (FDA) has approved modifications to the Risk Evaluation and Mitigation Strategies (REMS) for platelet-booster drugs Nplate (romiplostim) injection and Promacta (eltrombopag) tablets. The modifications include the removal of certain elements of the REMS, including the requirements for restricted distribution and additional safety data collection.
Avatar f tn i get my heart checked every 2 weeks now and i am fine with the qt thing. i take the chemo pill called gleevec and have to force myself to eat so i dont get sick when i take it. how long will these withdrawel problems go on? i have xanax to take (1mg) but dont work to good. i should would appreciate any advice from any one on how to deal with these issues, family dr says its anxiety but i think its the withdrawels from the high dose of elavil.
4437866 tn?1388119624 Put not but sorry but it does help lol and leave it in there..
Avatar m tn I should mention that I have CML but it has been in remission for the last two years and I am no longer taking Gleevec. I am scheduled to be looked at by a group that kills the nerve endings in the heart that causes AF but there is an 18 month waiting period. My question is how many times can I be cardioverted and what is the downside of having it so often?
225036 tn?1294509400 s post - the pill is called Gleevec. It is primarily for leukemia, but it is one of the treatments my doc at MD Anderson has in his back pocket ready to give me if the time comes that I need it. Becky, I know you are facing the fact that you are out of chemo's to try. But I'm wondering about Gleevec. I don't think it is an approved ovarian cancer treatment, but right now is critical. Wonder if your doc would consier trying it. I hope the Vitamin C infusions are helping.
Avatar n tn * buprenorphine Metabolized into norbuprenorphine by cytochrome-P450 isoenzyme 3A4 * Tyrosine kinase inhibitors, including Gleevec and Tasigna, used to treat chronic myelogenous leukemia and gastrointestinal tumors.
Avatar f tn There is no genetic basis for the CML therefore she was not put on Gleevec. She is on Hydrea to keep the wbc count down to a more normal level. I think the only thing that led to the CML diagnosis was the extremely high wbc with no sign of infection or other cancer. Mayo did the same blood tests as the hometown doctor, as well as the lab in Iowa City. I would like them to run other tests but havent a clue what to ask for.
Avatar f tn Meanwhile, in mice that were prone to develop neurofibromas, the cancer drug Gleevec — an inhibitor of c-kit — reduced the metabolic activity and size of the tumors. Because Gleevec is already prescribed for chronic myelogenous leukemia and other cancers, the researchers were able to secure fast regulatory approval for a phase 2 clinical trial of the drug in children and adults with neurofibromatosis type 1.
765775 tn?1366024691 FDA May Remove or Limit Access to Opioid Pain Medications The FDA is currently developing what they term “Risk Evaluation and Mitigation Strategies” or REMS in relation to opioid pain medications. What that means is they are working on a plan to ensure that the benefits of opioid medications outweigh the risks, which include misuse, abuse and accidental overdose. It's no secret that the abuse of prescription drugs has increased dramatically over the past several years.