I've tried to reduce on a few occasions, but I really feel it, and since I don't experience any side effects from this med, I stay on the high
dose. I also take 60-80mg of nortriptyline at night. I get greater pain relief with this combination of these two meds than on either of them on their own. And yes, I do notice when I miss a dose of either one. Are you taking Neurontin for neuropathic pain? You definitely have room to increase. Talk to your doc.