Hi, Rita. I don't have osteoporosis, but I do have osteopenia (less than 2.5 standard deviations off). Have been treating this for many years, first with Boniva, then with Reclast. I'm way overdue for another Reclast infusion. For the last one, I didn't feel great for a day or so afterwards, but it wasn't all that bad either.
I really doubt that this has anything to do with MS meds. It's largely hereditary, but aside from that, who knows?