Fluvastatin metabolism

Common Questions and Answers about Fluvastatin metabolism

lescol

There is currently a Phase II study going on with Fluvastatin along with regular SOC treatment and because Fluvastatin, like Alinia, is already an approved drug, it would be available sooner and more easily than the PI drugs, for example, currently in trial. http://www.hepatitis-central.com/mt/archives/2008/04/fluvastatin_low.html These links really made me sit up and take notice.

The discovery of the mechanisms by which HBV is controlled by the hepatic metabolic milieu may broaden our understanding of the unique regulation of HBV expression and may also explain the mechanisms by which HBV induces liver pathologies. The emerging principle of the intimate link between HBV and liver metabolism can be further exploited for host-targeted therapeutic strategies.

Virtually all patients taking a statin were on simvastatin (n=25); 2 were on lovastatin, 2 on atorvastatin and 1 on fluvastatin. The pooled SVR rate* for the 104 patients on standard treatment was 37%. This is the highest SVR ever reported in the medical literature for a VA based population. The pooled SVR rate for the triple therapy group was 63%. In terms of HCV subgroups, the effect was statistically strongest for genotype one, the most difficult subgroup to treat.

Accordingly, Plavix may interfere with the metabolism of phenytoin, tamoxifen, tolbutamide, warfarin, torsemide, fluvastatin, and many non-steroidal anti-inflammatory agents, but there are no data with which to predict the magnitude of these interactions. Caution should be used when any of these drugs is co administered with Plavix.

At high concentrations in the blood, clopidogrel (plavix) inhibits the activity of the enzyme which metabolizes (eliminates) warfarin (Coumadin), a "blood thinner". This could lead to an increase in levels of warfarin and increase the risk of bleeding due to over-thinning of the blood. To date there have been no reports of an important interaction in humans between warfarin and clopidogrel.

atorvastatin, fluvastatin, lovastatin, pravastatin and simvastatin. When the statins were tested alone, all except pravastatin inhibited HCV replication. Fluvastatin had the strongest effect. Atorvastatin and simvastatin had moderate effects while lovastatin had a weak effect. ...

Coadministration with potent inhibitors of CYP450 3A4 including telaprevir may significantly increase the plasma concentrations of certain HMG-CoA reductase inhibitors and their pharmacologically active metabolites that are primarily metabolized by the isoenzyme.

I guess my bad lipid #'s helped with me acheiving a RVR and being Unde at 12 weeks post.

, of the School of Nursing at the University of Rochester Medical Center, an expert on drug interactions, explains that grapefruit juice is one of the foods most likely to cause problems with drugs, because it is metabolized by the same enzyme in the liver that breaks down many drugs. The cytochrome P-450 3A4 enzyme breaks down grapefruit juice into useful components for body, just like it breaks down dozens of medications.

John's wort, Zyban/Wellbutrin (bupropion), Paxil (paroxetine), Prozac (fluoxetine), Luvox (fluvoxetine) Serzone (nefazodone), Zoloft (sertraline), Effexor (venlafaxine) antihistamines - Hismanal (astemizole), Seldane (terfenadine) antifungals - itraconazole (Sporanox), Ketoconazole (Nizoral) gastrointestinal motility agents - Prepulsid (Cisapride) ergot drugs - Ergonovine, Ergomar (ergotamine) anti-psychotics - Clozaril (clozapine), Orap (pimozide) sedatives/sleeping pills - Ambien (zolpi

[15] Strong in vitro inhibition of HCV replication has also been achieved with the combination of interferon with fluvastatin.[16] Rosuvastatin is believed to target a compound called geranylgeraniol, which plays a role in the last stages of cholesterol synthesis. It has a long half-life as it is not readily metabolized by the cytochrome P450 system. Furthermore, the drug is considered to be safe in patients with underlying aminotransferase elevation.

Hi Ev, Here's a radical thought that I'll toss out to you...fluvastatin. It's a statin used to treat high cholesterol but has been found to significantly lower the viral load. I'll include some links. There are were initially some concerns about it's impact on the liver but not enough to prevent it's usage for persons with Hep C, only to be aware of it and to monitor .. not much different than monitoring other vitals and bloods while on treatment.

) Co Reduced expression of Jak-1 and Tyk-2 proteins leads to interferon resistance in hepatitis C virus replicon. Hazari S, Taylor L, Haque S, Garry RF, Florman S, Luftig R, Regenstein F, Dash S. Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, USA. BACKGROUND: Alpha interferon in combination with ribavirin is the standard therapy for hepatitis C virus infection.

In addition, combined treatment with each of the three nutrients and interferon alpha or beta or fluvastatin inhibited HCV RNA replication in an additive manner, while combined treatment with cyclosporine synergistically inhibited HCV RNA replication. In contrast, we found that vitamin E enhanced HCV RNA replication and negated the effects of the three anti-HCV nutrients and cyclosporine but not those of interferon or fluvastatin.

I think as long as you are not taking any drugs that are metabolized in the p450 system, and you can look them up as Marcia suggested above you can take it. Interferon and ribavirin are not metabolized there so if that is all you are taking go ahead, at the recommended dose. I would not turn down help from any quarter in beating this virus! DTD http://www.medhelp.

) There took place end of october an FDA/NIH-organized conference just before AASLD meeting about regulatory issues, the anti-HCV potential of statins was mentioned there among the leading other drug options under development. I (obstinate non-responder) am now considering taking preferably fluvastatin (off-label) despite the fact having no elevated cholesterol levels. I need some search work to provide you with all these important links, I hope later on the day I'll the time for it....

My first blood test showed a drop in my ALT, AST, And my VL dropped fron 1,450,000 to 220,000 it wasn't quite a log but i am incouraged. I have found out by research and this site that the liver metabolizes every thing and its where cholesteral is produced so maybe if your liver gets in better shape some of your other health issues would get in check. I do believe that doing treatment before their is much damage and your in relatively good health makes it easier to handly the side effects.

Thus, having higher LDL or cholesterol levels prior to treatment might indicate a good outcome only for patients with genotype 1 or 2, not for patients infected with genotype 3. This could be a result of alteration in beta-lipoprotein metabolism induced by genotype 3a by interfering with the synthesis of cholesterol in hepatocytes.

) Hep C affects our immune sytems and our livers. Your liver plays a big role in the production of hormones and metabolic processes. Im not suprised the doc thinks dealing with Hep C prior to trying to trying to get pregnant is a good idea. You probably are feeling like you are runningout of time and now this problem has arisen, but try not to let it get to you. Try not to get discouraged. I agree with the others, you need to see a Heptologist if possible and you need a lot more info.

a very good example is the diet i used to clear my fatty liver and results showed up in as little as few months, that diet is the same for all metabolic related diseases, cancer prevention included.it has very little proteins so legumes must be included to balance the almost zero meat/diary products http://www.medhelp.org/posts/Hepatitis-B/update-on-my-fatty-liver/show/1500346 http://www.medhelp.

Recommended

MedHelp Health Answers

Submit