Fluvastatin hepatitis c
Common Questions and Answers about Fluvastatin hepatitis c
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Though statins have not been extensively studied in people with hepatitis C, it is often the case that drugs that have the potential to cause hepatotoxicity are more likely to do so in patients with pre-existing liver disease.
One recent study, however, found that statins did not appear to increase the risk for hepatotoxicity in patients with hepatitis C.
S.
From "Fluvastatin Inhibits Hepatitis C Replication in Humans"
http://www.sovegastro.com/pdf/Fluvastatina%20inhibe%20replicacion%20HVC%20en%20humanos.pdf
From "Comprehensive Analysis of the Effects of Ordinary Nutrients on Hepatitis C Virus RNA Replication in Cell Culture."
"We found that three nutrients—ß-carotene, vitamin D2, and linoleic acid—inhibited HCV RNA replication and that their combination caused additive and/or synergistic effects on HCV RNA replication.
Researchers have investigated the effect of statins on hepatitis C for several years, but the treatment is not approved by FDA. In fact, use of many statins is contraindicated in patients with active liver disease. However, FDA recently removed this contraindication from the package inserts of 3 statin agents, and literature reports indicate that only approximately 10% of patients experience deviations in ALT levels with statin use and that any elevation is often temporary, Dr Bader said.
1383-1389.
9. Torres DM, Harrison SA. HCV replication and statin pleiotropism: an adjuvant treatment panacea? Am J Gastroenterol. 2008;103:1390-1392.
10. Ferro D, Basili S, Praticó D, Iuliano L, FitzGerald GA, Violi F. Vitamin E reduces monocyte tissue factor expression in cirrhotic patients. Blood. 1999;93:2945-2950.
11. Konishi M, Iwasa M, Araki J, et al.
well there is clinical trials for something called vx-950 or vertex 950 that is used in combination therapy with the already existing interferon or ribaviron/ roche brands are pegasys and copeagus
there has also been advances made with a already approved drug called Fluvastatin in conjuction with interferon and ribaviron that studies show have a better success on lowering viral load.
//archive.mail-list.com/hbv_research/message/20091204.135403.37fd5fc6.en.html
Simvastatin potentiates the anti-hepatitis B virus activity of FDA-approved nucleoside analogue
http://archive.mail-list.com/hbv_research/message/20100603.135550.e1051511.en.
In contrast, we found that vitamin E enhanced HCV RNA replication and negated the effects of the three anti-HCV nutrients and cyclosporine but not those of interferon or fluvastatin. These results will provide useful information for the treatment of chronic hepatitis C patients who also take anti-HCV nutrients as an adjunctive therapy in combination with interferon.
(AASLD Nov 2008)
Vitamins B depletion, lower iron status and decreased antioxidative defense in patients with chronic hepatitis C treated by pegylated interferon alfa and ribavirin.
Lin CC, Yin MC, et al, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung City, Taiwan, Republic of China.
Our observations are similar to those of Delang et al, for an entirely different virus, hepatitis C. They showed synergistic effects for all 10 protease and polymerase inhibitors tested individually in conjunction with simvastatin. However, the latter group did not propose any potential mechanism for this synergistic activity (Delang et al., 2009).
//www.cdc.gov/hepatitis/c/cfaq.htm
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As the number of people realizing they have HCV continues to rise, so does the concern of how they were originally infected with this disease. Since medical experts agree that Hepatitis C is only transmitted through the blood, a majority of cases are contracted through IV drug use or tainted blood transfusions. However, an estimated 10 percent of those infected cannot determine how they contracted Hepatitis C in the first place.
i did all my tests about Hepatitis C,they shows that i have hepatitis C after thet they test my blooth again i was wait 7 days for the results then it show that i dont have Hepatitis C,Doctors says I was in touch somehow with hepatitis C but it was gone from me, and thay says that i am healthy i dont need any treatments,but i am still worry why it shows in my blooth that i still have Hepatitis C??? can u answer me on this question ,i am so afraid ,do i need to go to see other Doctors or???
//www.cdc.gov/hepatitis/hcv/cfaq.htm#B1
Hepatitis C infected blood needs to enter the blood stream of an uninfected person. You would need an open fresh wet injury as would the other person.
Assuming the other person is infected with hepatitis c their blood must get into your blood stream.
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