I'm just wondering, has anyone used 'out of date' puregon before? I opened a new cartridge on August 12, but only used one dose, as I had over-responded, growing too many follies. There is still about 325iu in the cartridge. It's in the fridge, and my RE told me the other day I could use it for my next cycle. It will be by then about 40 days since it was opened. Two of the nurses told me I shouldn't use it, and I was just wondering, if anyone has any ideas here?