Felodipine pharmacokinetics
Common Questions and Answers about Felodipine pharmacokinetics
plendil
However, since the accidental discovery of an interaction between the calcium channel blocker, felodipine, with grapefruit juice,1 it has now become evident that grapefruit juice has the potential to alter the plasma concentrations of many medications when they are taken by mouth. In some cases, this may result in undesirable clinical effects of medications.
- Absorption, oral: time to peak concentration 7h
- Elimination half-life = 12 h
(It says also that in general it can be administered once daily because it has a 24 h effect.Why?)
- Can you give another example to clarify it better please?
- When it says divide in 2 doses , does it mean only in the morning and dinner? 3 doses (morning-lunch-dinner)?
Thank you for taking the time to answer!!
Hormones like estrogen (in birth control pills or hormone replacement therapy) and testosterone
Blood pressure medicines called calcium channel blockers (such as nifedipine, amlodipine, diltiazem, felodipine, and verapamil)
Steroids
Antidepressants, including MAO inhibitors (such as phenelzine and tranylcypromine) and tricyclics (such as nortriptyline, desipramine, and amitriptyline)
Home Care
Elevate your legs above your heart while lying down.
hello 5 weeks ago i woke up to find my left eye had what i can only describe has a frosty shadow over it i left it for two weeks thinking it was just floaters no change so went to the doctors who gave me a blood pressure test found it was high and put me on felodipine prolonged release tablets 2.
I can't help out on the pharmacokinetics, but your reasoning is sound: it doesn't make sense to dose so that the drug runs out.
I'd query Schering-Plough as well as your hepatologist, if I were you.
Please give me a heads-up if you solve the riddle.
In June '08 I was sitting watching TV when my left side from my head down to my leg became stiff and numb. Went to the ER and checked by 5 neuronogists, had scans, MRI & other tests. Their consensus was a brain event in the rt. thalemus. For 2 & 1/2 yrs I was living with a 5 out of 10 sensation but last Dec. '10 as I was having dinner, the sensation became worse like an 8 out of 10 and I'm having increased trouble moving my whole left side.
Coadministration with the hepatitis C virus (HCV) NS3/4A protease inhibitors, boceprevir and telaprevir, may increase the plasma concentrations and pharmacologic effects of calcium channel blockers, especially the dihydropyridines (e.g., amlodipine, felodipine, nicardipine, nifedipine, nisoldipine). The mechanism involves inhibition of intestinal and hepatic CYP450 3A4, the isoenzyme primarily responsible for the metabolic clearance of most calcium channel blockers.
I am active, never sick but use eyedrops for Glaucoma, very slightly elevated blood pressure for which I take a mild 5 mg. Felodipine tab and vytorin for slightly elevated cholestrol. My chol. ratio with meds is 2.3.
The last week I have had a great slowing of my pulse. For three days it didn't get over 42 and on one day if got down as low as 37 and then 38 and stayed there all day. My blood pressure has been about the same as it always is....
Hormones like estrogen (in birth control pills or hormone replacement therapy) and testosterone, Blood pressure medicines called calcium channel blockers (such as nifedipine, amlodipine, diltiazem, felodipine, and verapamil), Steroids, Antidepressants, including MAO inhibitors (such as phenelzine and tranylcypromine) and tricyclics (such as nortriptyline, desipramine, and amitriptyline).
Hepatic Impairment
In volunteers with hepatic impairment (Child-Pugh Class A and B), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (47% for Cmax and 85% for AUC). The pharmacokinetics of sildenafil in patients with severely impaired hepatic function (Child-Pugh Class C) have not been studied. A starting dose of 25 mg should be considered in patients with any degree of hepatic impairment [see Dosage and Administration (2.5) and Clinical Pharmacology (12.3)].
Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..."
It however says that initiation of Folic acid and phenytoin together is beneficial.
Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
The Phase 1 trial was designed to characterize the safety profile of ARC-520 across a range of doses and evaluate pharmacokinetics. It is a single-center, randomized, double-blind, placebo-controlled, single dose-escalation, first-in-human study of ARC-520 administered intravenously to healthy adult volunteers. All subjects have been dosed and received either placebo or ARC-520 in doses ranging from 0.01 mg/kg to 2 mg/kg.
i believe in the pre-clinical trials with healthy volunteers, researchers used Carbon14 to gauge the half-life and paths of elimination during pharmacokinetics studies. it is a common practice. perhaps that is what you are thinking about?
Nitazoxanide, brand name alinia, had also excellent ed50 results in an in vitro inhibition study, just as good as lamuvidine, so this sounded fascinating for a possible combination towards true synergism, to finally suppress virion production to a level so low that the silent daily reinfection will be reduced, allowing a slow net clearance of infected cells with a resulting drop in surface antigen.
Completely absorbed from the GI tract. Sodium salt (Anaprox) is more rapidly absorbed.
Distribution: Crosses the placenta; enters breast milk in low concentrations.
Protein Binding: >99%.
Metabolism and Excretion: Mostly metabolized by the liver.
Half-life: 10–20 hr.
CONTRAINDICATIONS AND PRECAUTIONS
Contraindicated in:
Hypersensitivity
Cross-sensitivity may occur with other NSAIDs, including aspirin
Active GI bleeding
Ulcer disease.
i am 62+ male i have been having hypothyrodism for around 2 decades this was discovered when i had elevated liver enzymes now its normal i am having hypertension right branch bundle block perhaps congenital i took fosamax weekly for osteoporosis for about 5 years i had enlarged prostrate gland recent abdominal echo report say size normal i am on urimax futher for hypertension i am on felodipine 5mg and losartan potasium 25 mg and it is under control I was recently admitted to hospital for a tra
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