Ezetimibe study

Common Questions and Answers about Ezetimibe study

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Avatar m tn Ezetimibe might work moderately in ways not related to ntcp blockage, so it is possible that some benefit can be had in adding it to the tdf ifn combo. We have detailed knowledge now that ntcp blockage has to be very high to achieve a realistic inhibition of HBV entry this way. Myrcludex in doses 20mg or more are needed to block ntcp sufficiently to limit reinfection to the extent needed.
Avatar m tn There was an in vitro study on ezetimibe inhibiting HBV DNA production. The ed50 was fairly low and in a similar range as lamuvidine. So it looked very interesting. But in an in vitro study you have a constant exposure to the drug, which is impossible to achieve in vivo. And the cells used are not the same as regular hepatocytes in human liver, with many differences in gene expression and cellular physiology.
Avatar m tn also statins like simvastatin were reported to boost response a little but better not mix 2 statins, in a report researchers of ezetimibe effect on hbv and hcv suggested the use of ezetimibe with interferon but without simvastin ezetimibe dose is 10-20mg daily but human trials with dose 50mg daily for a limited time did not find any sides or toxicity
Avatar m tn A recent paper studied the effect of most FDA approved drugs on the inhibition of NTCP, the now known entry receptor for HBV. Ezetimibe was found to have a 50%inhibition conc of 25micromolar, while irbesartan, a commonly used angiotensin inhibitor to reduce blood pressure, was found to inhibit at 11.9 micromolar. Both compounds have similar MW, but irbesartan is given at up to 300mg per day, while exetimibe is dosed at 10mg.
Avatar m tn The FDA-approved drug ezetimibe (sold under the trade-name Zetia) is readily available and perfectly targeted to the receptor, Sainz said, so the researchers had an ideal method for testing NPC1L1's involvement in HCV infection. The researchers showed that ezetimibe inhibited HCV infection in cell culture and in mice transplanted with human liver cells. And, unlike any currently available drugs, ezetimibe was able to inhibit infection by all six types of HCV.
Avatar n tn You could consider going for a higher dose of Lipitor, another way to go is to consider taking a drug that limits cholesterol absorption such as Ezetimibe. There is a combination drug Simvastatin and ezetimibe that may be better in controlling cholesterol. Discuss these drugs with your doctor. Best of luck to you. Stay positive.
Avatar m tn “We’ve been working on a pair of natural proteins called LXRα and LXRβ that stimulate fat production in the liver, and we thought our compound might be able to successfully suppress this process,” said Thomas Burris, a professor at TSRI who led the study, which was recently published in an online edition of the journal ACS Chemical Biology.
Avatar f tn Crestor is a statin (rosuvastatin calcium) only, Vytorin is a statin (Simvastatin) with Zetia (ezetimibe). Statins work by controlling the production of cholesterol in your liver while Zetia works by preventing cholesterol to be absorbed in your digestive system. Of the two, Crestor is the stronger of the two. In addition, recent trials have shown that adding Zetia does not improve the performance of Vytorin over Simvastatin alone.
Avatar m tn Here's the rest of the story; "The memory loss issue was more anecdotal from adverse event reporting and not from formal studies, the FDA said, adding that there was no proof that the problem was caused by statins but that it wanted people to be aware of the possibility. One safety warning long associated with the class of medicines will be reversed, the FDA said.
1006041 tn?1250396768 I was given an additional medicine which dramatically decreases the absorbtion of fats through the digestive tract. This is called Ezetimibe and just 10mg reduced my cholesterol a great deal. Maybe your GP could look to attacking your problem from this angle?
Tbd About two years ago my doctor added ezetimibe to my regimen. It has been lowering my bad cholesterol how ever the first of this month I missed taking them for about a week and for the first time in years I felt less fatigued. I do have Fibromyalgia which is usually the cause of my fatigue, but this is a different type of fatigue. I have not restarted either of the cholesterol meds back because I have felt so much better. I know I need to talk to my doctor about it.
Avatar n tn I had very high cholesterol, due to familial hypercholesterolemia, and living on just salad for weeks did nothing for the levels. Statins have worked wonders in bringing the levels down but I also take Ezetimibe which slows absorption of fats through the gut lining. Now I can basically eat what I want and my cholesterol levels are always within the range required. Cholesterol in the blood is not the cause of disease, it's like a side effect from the initial problem.
529224 tn?1400648219 Statins reduced the cholesterol significantly and with the added medication of Ezetimibe, which slows fat absorption through the gut wall, my cholesterol is way below average now. I've been on these medications since the start of 2007 with no side effects which blood tests have continually confirmed. Familial hypercholesterolemia affects 1 in 500 people in many countries, so it isn't that uncommon.
645800 tn?1466860955 Vytorin is a combination Ezetimibe and simvastatin and I'm currently taking simvastatin. My doctor is switching my medicine due to my leg cramps to see if that will help. All of the cholesterol "statin" medicines can cause muscle cramps. This one works in the gut to keep your body from getting the cholesterol into your body in the first place.
Avatar n tn If this fails, which it did with me, then your statins need a turbo boost but from a different angle which will not affect the liver. We consume around 25% of fats through food and so a good drug such as Ezetimibe works wonders with statins because it helps block fat absorption through the gut lining. This method dramatically increased my HDL and lowered my LDL and trigs to rock bottom. Actually after starting this regime, my disease didn't increase for a year and has remained static.
5276663 tn?1370490115 I was offered a Study on Asthma, Medication Is called, Sinaclar,the Study last 17 Weeks, Is this an Option for me? I do have scoliosis,and asthma, will this Interfere in my Health,?