Ezetimibe structure
Common Questions and Answers about Ezetimibe structure
zetia
also statins like simvastatin were reported to boost response a little but better not mix 2 statins, in a report researchers of ezetimibe effect on hbv and hcv suggested the use of ezetimibe with interferon but without simvastin
ezetimibe dose is 10-20mg daily but human trials with dose 50mg daily for a limited time did not find any sides or toxicity
The FDA-approved drug ezetimibe (sold under the trade-name Zetia) is readily available and perfectly targeted to the receptor, Sainz said, so the researchers had an ideal method for testing NPC1L1's involvement in HCV infection.
The researchers showed that ezetimibe inhibited HCV infection in cell culture and in mice transplanted with human liver cells. And, unlike any currently available drugs, ezetimibe was able to inhibit infection by all six types of HCV.
You could consider going for a higher dose of Lipitor, another way to go is to consider taking a drug that limits cholesterol absorption such as Ezetimibe. There is a combination drug Simvastatin and ezetimibe that may be better in controlling cholesterol. Discuss these drugs with your doctor.
Best of luck to you. Stay positive.
A recent paper studied the effect of most FDA approved drugs on the inhibition of NTCP, the now known entry receptor for HBV. Ezetimibe was found to have a 50%inhibition conc of 25micromolar, while irbesartan, a commonly used angiotensin inhibitor to reduce blood pressure, was found to inhibit at 11.9 micromolar. Both compounds have similar MW, but irbesartan is given at up to 300mg per day, while exetimibe is dosed at 10mg.
no study for its activity on hbv, we do know it has activity but the trial has never started
simvastatin lowers hcc 50% and prevents fibrosis/cirrhosis so it is indicated on all hbver, this has thousands of pateints studied for decades to find this data on hcc
you better use simvastatin instead other statins, also ezetimibe has in vitro effect on hbv so these are the best choices on hbvers
Hi, I had a mammogram Aug 27th which that the small node I have had for years has grown. Two days later I had an ultrasound that shows a hypoechoic structure deep within the chest wall and has a hyperechoic notch to it with an appeappearance of a benign lymph node but does not correlate with the position of the mammogram. Given the findings of this ultrasound and enlargemnt of the density on the mammogram biopsy is recommended. My question is would you take it out completely?
t know very much about the molecular structure. I find it a bit hard to understand, but I get pieces of it.
This one seemed more concise then the the last one I sent you.
- Dave
http://www.natap.org/2001/jun/MoleBio.
There was an in vitro study on ezetimibe inhibiting HBV DNA production. The ed50 was fairly low and in a similar range as lamuvidine. So it looked very interesting. But in an in vitro study you have a constant exposure to the drug, which is impossible to achieve in vivo. And the cells used are not the same as regular hepatocytes in human liver, with many differences in gene expression and cellular physiology.
About two years ago my doctor added ezetimibe to my regimen. It has been lowering my bad cholesterol how ever the first of this month I missed taking them for about a week and for the first time in years I felt less fatigued. I do have Fibromyalgia which is usually the cause of my fatigue, but this is a different type of fatigue. I have not restarted either of the cholesterol meds back because I have felt so much better. I know I need to talk to my doctor about it.
Within the left ovary is a complex cystic structure measuring 4.4 x 4.8 x 4.5 cm. Some sepatation is present with half of the cystic structure having either dense internal debris or a somewhat solid component. No color flow is appreciated in this abnormal half of the cystic structure. No other mass or lesion or free fluid is present wihtin the left adnexa. This is a nonspecific finding and both benign and malignat etiologies must be considered.
i had a ct scan done the said in the left adnexa there is a structure with 2 cystic areas measuring 12 and 16 mm each and has enhancing perphery i have had a hysterectomy 4 yrs ago what does thids all mean it also states i have several diverticulae in sigmoid colon but no evidence of diverticlitis what does this mean please
My doctor called and told me an irregular cystic structure was found on my left ovary along with a cyst. Could this be an ectopic pregnancy? I have had all the signs of being pregnant. This is frustrating because no one seems to be telling me anything.
My right side of my abdomen was killing me a week later I ended up in the er with severe pain and bleeding. An inner and outer US showed a 6.8cm separated cystic structure and ovarian lesion. I was told to followup with my OBGYN. Which I did. She said to wait 6-8 weeks and do a repeat US. Well I was referred to a new dr. since my old obgyn retired from that practice. The new dr. has been much more sympathetic. I saw her last friday 1/8 and she ordered more blood tests (Ca-125, Ova-1, Estradiol.
I had very high cholesterol, due to familial hypercholesterolemia, and living on just salad for weeks did nothing for the levels. Statins have worked wonders in bringing the levels down but I also take Ezetimibe which slows absorption of fats through the gut lining. Now I can basically eat what I want and my cholesterol levels are always within the range required.
Cholesterol in the blood is not the cause of disease, it's like a side effect from the initial problem.
Recommended
