Ezetimibe simvastatin side effects
Common Questions and Answers about Ezetimibe simvastatin side effects
zetia
Hi there and thanks for your question and joining the forum. Please always check in with your doctor on these matters so they can guide you. Unusual tiredness and weakness is listed as a 'less common' side effect of Simvastatin. https://www.mayoclinic.org/drugs-supplements/simvastatin-oral-route/side-effects/drg-20069006. For most people it doesn't cause significant issues, however. With all medications, weighing risks and benefits to taking the medication must be done.
curious if stef2011 or studyforhope or StephenCastlecrag know whether simvastatin by itself can reduce viral load? I've read about the effects in conjunction with NUCS but I'm curious if sim is effective alone.
Have you been on Simvastatin long? Side effects normally do not start after 90 days of use. Your other drugs may be causing the problem, especially the Neurontin which has concentration problems as a main side effect which can get worse the longer you take it.
If you feel it is the Simvastatin, you can always ask your doctor about going off of it for a short while to see if it improves. This is a rare side effect of Simvastatin so I would look elsewhere for the problem.
Crestor is a statin (rosuvastatin calcium) only, Vytorin is a statin (Simvastatin) with Zetia (ezetimibe). Statins work by controlling the production of cholesterol in your liver while Zetia works by preventing cholesterol to be absorbed in your digestive system.
Of the two, Crestor is the stronger of the two. In addition, recent trials have shown that adding Zetia does not improve the performance of Vytorin over Simvastatin alone.
no study for its activity on hbv, we do know it has activity but the trial has never started
simvastatin lowers hcc 50% and prevents fibrosis/cirrhosis so it is indicated on all hbver, this has thousands of pateints studied for decades to find this data on hcc
you better use simvastatin instead other statins, also ezetimibe has in vitro effect on hbv so these are the best choices on hbvers
So in summary, ezetimibe or irbesartan are no match to the power of myrcludex to inhibit ntcp, but it needs to be blocked so strongly, that the side effects from impairment of its natural function become the limiting factor.
The experiments with the chimeric mice used a dose of 2mg per kg and the human part of the chimeric liver only contains ntcp and needs to be blocked. The mouse liver has other transporters to clear the bile acids from the portal blood and furthermore, mice do not complain.
also statins like simvastatin were reported to boost response a little but better not mix 2 statins, in a report researchers of ezetimibe effect on hbv and hcv suggested the use of ezetimibe with interferon but without simvastin
ezetimibe dose is 10-20mg daily but human trials with dose 50mg daily for a limited time did not find any sides or toxicity
Generally, if you experience muscle weakness as a side effect of Lipitor (atorvastatin), other statins will produce similar effects, so that eliminates the use of Zocor (simvastatin), Crestor (rosuvastatin) etc.
After statin therapy fails or is not tolerated, it is normal to try ezetimibe (Zetia), which you said did not work. The use of colesevelam (WelChol) is not high, and is often the 'last ditch effort' to lower cholesterol.
There is a combination drug Simvastatin and ezetimibe that may be better in controlling cholesterol. Discuss these drugs with your doctor.
Best of luck to you. Stay positive.
According to Wikipedia, Ezetimibe has side effect - "it increased the thickness of artery walls and caused more major cardiovascular events"
Fatigue and lethargy are side effects of atenolol, however, I do not see any information suggesting that muscle weakness is a side effect of atenolol. I see that you also take Vytorin. It appears that symptoms of ALS,( Lou Gehrig's Disease) have been reported to the FDA in a higher than expected number of patients taking statins. ALS is a progressive motor neuron disorder with symptoms such as difficulty walking or standing, difficulty with fine motor skills and muscle paralysis.
Actually, Lipitor is much stronger than Simvastatin and has a much higher incidence of side effects, unless I have missed some new data. According to the links I have Simvastatin is the safest statin on the market.
I take Simvastatin with no side effects, and have for several years, and so does my husband, also no problems. It's done an excellent job of lowering both our cholesterols.
The study found that the patients on simvastatin achieved the target LDL level of less than 130, more than those on pravastatin (65 percent on simvastatin versus 35 percent on pravastatin). The most common side effects of the statins in general are nausea, gas, and upset stomach. Less common are headache, dizziness, rash, sleep disturbances, muscle pain, cramps, or weakness.
Hi,
Simvastatin is generally well-tolerated and side effects are rare. Minor side effects include constipation, diarrhea, fatigue, gas, heartburn, and headache. Major side effects include abdominal pain or cramps, blurred vision, dizziness, easy bruising or bleeding, itching, muscle pain or cramps, rash, and yellowing of the skin or eyes.
ref:http://www.medicinenet.com/simvastatin/article.htm
This could be an allergic reaction to the drug. It will stop if the drug is withdrawn.
I am a 62 year-old male who has been taking simvastatin for about 30 years. All of my cholesterol-related numbers are in a healthy range, and I have never experienced any serious side effects (e.g., muscle weakness, kidney and liver impairment, etc.). I have, however, had trouble sleeping for the past several years (perhaps caused by simvastatin, perhaps not). More importantly, I have been experiencing back pain for the past few months and would like to try CBD.
In one huge survey, atorvastatin came out on top with the least side effects. Here is some info regarding your question which I found on the internet.....
Atorvastatin 10mg reduced LDL by 30-40% = equivalent to 20mg Simvastatin
Atorvastatin 40mg reduced LDL by 46-50% = equivalent to 80mg Simvastatin
Starting doses for each of the two statins are ....
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