Ezetimibe rhabdomyolysis
Common Questions and Answers about Ezetimibe rhabdomyolysis
zetia
Crestor is a statin (rosuvastatin calcium) only, Vytorin is a statin (Simvastatin) with Zetia (ezetimibe). Statins work by controlling the production of cholesterol in your liver while Zetia works by preventing cholesterol to be absorbed in your digestive system.
Of the two, Crestor is the stronger of the two. In addition, recent trials have shown that adding Zetia does not improve the performance of Vytorin over Simvastatin alone.
The earlier mentioned side effect caused by the group of medications known as the statins, which Vytorin (ezetimibe/simvastatin) is a member of, is called rhabdomyolysis. This condition is breakdown of the muscle and has been associated with the statins as a class as a rare but serious side effect. Rhabdomyolysis caused by statins is reversible once the medication has been discontinued.
For patients found to have statin-induced rhabdomyolysis, consideration should be given to switching to an alternate LDL-lowering drug such as ezetimibe, a recently approved inhibitor of intestinal cholesterol absorption.
Refer: http://www.cmaj.
also statins like simvastatin were reported to boost response a little but better not mix 2 statins, in a report researchers of ezetimibe effect on hbv and hcv suggested the use of ezetimibe with interferon but without simvastin
ezetimibe dose is 10-20mg daily but human trials with dose 50mg daily for a limited time did not find any sides or toxicity
What will happen if an athlete with Rhabdomyolysis continues to play his sport? What will happen in the long run?
The FDA-approved drug ezetimibe (sold under the trade-name Zetia) is readily available and perfectly targeted to the receptor, Sainz said, so the researchers had an ideal method for testing NPC1L1's involvement in HCV infection.
The researchers showed that ezetimibe inhibited HCV infection in cell culture and in mice transplanted with human liver cells. And, unlike any currently available drugs, ezetimibe was able to inhibit infection by all six types of HCV.
Since you know your CK levels, I assume you've seen a doctor about this? Do you have other symptoms, like muscle tenderness, nausea, etc?
In any case, high CK and dark urine are among the signs of rhabdomyolysis (google it), which is not a Good Thing. It's a breakdown of skeletal muscle. It can be caused by too- vigorous exercise, especially when dehydrated, among other things.
You could consider going for a higher dose of Lipitor, another way to go is to consider taking a drug that limits cholesterol absorption such as Ezetimibe. There is a combination drug Simvastatin and ezetimibe that may be better in controlling cholesterol. Discuss these drugs with your doctor.
Best of luck to you. Stay positive.
This intense pain is a symptom of rhabdomyolysis,a rare condition that causes muscle cells to break down. This does not make your muscle tissue "mushy", it just causes cells t breakdown.
The most common signs and symptoms of rhabdomyolysis include:
* Severe muscle aching throughout the entire body
* Muscle weakness
* Dark or cola-colored urine
These symptoms usually occur in the first 90 days of treatment and happen in less than 1% of those taking Lipitor.
Rhabdomyolysis is a life-threatening condition that results from myositis, a condition which destroys muscle cells causing pain, particularly in the calves and lower back. The condition can become so severe that it leads to kidney failure. Symptoms of rhabdomyolysis include, but may not be limited to, muscle pain, weakness, tenderness, fever, dark urine, nausea, and vomiting.
A recent paper studied the effect of most FDA approved drugs on the inhibition of NTCP, the now known entry receptor for HBV. Ezetimibe was found to have a 50%inhibition conc of 25micromolar, while irbesartan, a commonly used angiotensin inhibitor to reduce blood pressure, was found to inhibit at 11.9 micromolar. Both compounds have similar MW, but irbesartan is given at up to 300mg per day, while exetimibe is dosed at 10mg.
MB bands which are Cardiac Bands and MM bands which are muscle bands. Weight lifters or people with rhabdomyolysis can knock the MM bands way out of whack. Muscle breakdown will throw the MM band quite high.
About 4 years ago, I was overworked by a personal trainer in the gym and ended up in the hospital for 5 days due to Rhabdomyolysis. I had never heard of this disease before this day. Turns out the trainer overworked me. Needless to say, I am not a big fan of exercise since then. I've dabbled with it over the past few years.
Did your doctor prescribe 2,000 per day and is that what you took? Your post is also not clear when you say consecutive 3-4 dosing at 2,000.
Rhabdomyolysis, kidney problems so that I ultimately had to stop them, but knee burning/pain while walking wasn't one of them.
no study for its activity on hbv, we do know it has activity but the trial has never started
simvastatin lowers hcc 50% and prevents fibrosis/cirrhosis so it is indicated on all hbver, this has thousands of pateints studied for decades to find this data on hcc
you better use simvastatin instead other statins, also ezetimibe has in vitro effect on hbv so these are the best choices on hbvers
Those tests showed that my CPK levels exceeded 135,000 and i was diagnosed with Rhabdomyolysis. All other tests did not reveal the cause of the Rhabdomyolysis but no-one at the hospital seemed to have ever heard of cpk levels this high. My searches on the internet have also not revealed any levels nearing this. I am now down to 4000 (and hopefully dropping).
any thoughts?
have there been other cases with cpk levels exceeding 135,000 and what was the cause?
It can potentially be an early indicator of a very serious condition called rhabdomyolysis that can be a side effect. Dark urine can also accompany rhabdomyolysis. From what I see on line, creatinine kinase is what your doctor should have tested and if it is elevated, the drug should be discontinued.
Also my initial rhabdomyolysis diagnosis had my ck levels at 1300. No rheumatologist or neuromuscular doctor has given me an answer in what this could be.
So i got diagnosed with Rhabdomyolysis and im in the hospital and i just masturbated in the bathroom. Every morning i get a urine and blood test, when testing my urine they check for myoglobin and check my red blood cell count. My question is if i pee about 3-4 times an hour like i do now will the sperm show up in my urine test tomorrow and if so is there anything they test for that will be off enough to where they question it? And if so should i tell them i masturbated?
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