Estrogen receptor positive
Common Questions and Answers about Estrogen receptor positive
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A score of Estrogen Receptor positive (ER+) means that estrogen is causing your tumor to grow, and that the cancer should respond well to hormone suppression treatments. If the score is Estrogen Receptor negative (ER-), then your tumor is not driven by estrogen, and your results will need to be evaluated along with other tests, such as your HER2 status, to determine the most effective treatment.
Positive vs.
Hi. The estrogen receptor status of tumors can change over time. A mass of breast cancer is actually composed of a mixed population of cancer cells. Some cells are strongly ER positive, some only mildly so, and some are even ER negative (do not contain estrogen receptors). When exposed to an aromatase inhibitor like letrozole, those cells which are strongly ER positive are very susceptible to the effects of this drug and either die off or stop multiplying.
Hello -- I have been trying to find out whether consuming flax seed would interfere with the efficacy of the taxol / herceptin treatments that I am receiving for my breast cancer. I understand from a study done at the University of Toronto that flax seed may help to eliminate breast cancer. However, I would not want to consume anything that would interfere with my regular medical treatment. The cancer is in the left side of my lymph system. It is estrogen-receptor and HER-2 positive.
Tamoxifen is a selective estrogen receptor modulator, meaning that it targets estrogen in the breast independent of ovarian production of estrogen. However, if you have had your ovaries removed, then you would be postmenopausal and could possibly take an aromatase inhibitor instead of tamoxifen. Either way, if your breast cancer is hormone receptor positive, then hormone therapy would likely be recommended as the body does produce estrogen outside of the ovaries.
Pardon my ignorance, under Estrogen
Progesterone Receptor Immunoperoxidase Assay, it states Estrogen Receptor Assay Positive 80% of cells. Same for Progesterone. Possibly is this it,staining greater than 5% of cell nuclei is considered positive. OR HER2 gene ABSENT. Average copy number is 2.3. The HER2/CEP17 ratio is 1.2 (reference range is 0.8-1.7). I do not see anything else relating to your information given.
Do you know if your cancer was estrogen receptor postive? It is important to know that before you consider HRT. If it is estrogen receptor positive, then you definitely don't want to start taking hormones. Have you talked to your doctor about it? There are other things out there that can help with the symptoms that would be safer. Don't try OTC medications as they can mimic soy in the body, which cancer cells can view as estrogen. It sounds like you have your cancer under control.
also known as ER) is a gene that encodes an estrogen receptor protein, estrogen receptor α (ERα). ... The symbol ER generally refers to ERα.
ESR2:Estrogen controls many cellular processes including growth, differentiation and function of the reproductive system. Estrogen is also responsible for the growth and maintenance of the skeleton and the normal function of the cardiovascular and nervous systems.
Hello -- I have been trying to find out whether consuming flax seed would interfere with the efficacy of the taxol / herceptin treatments that I am receiving for my breast cancer. I understand from a study done at the University of Toronto that flax seed may help to eliminate breast cancer. However, I would not want to consume anything that would interfere with my regular medical treatment. The cancer is in the left side of my lymph system. It is estrogen-receptor and HER-2 positive.
When the biopsy was done, most likely they did a receptor test on it. They usually do ER PR which is estrogen and progestrone receptor tests. Tomoxifan is a estrogen hormone blocker. Most dcis is estrogen postive, however mine did happen to be negative. Blocking the estrogen has proven to decrease the chances of the dcis from returning. Once her lumpectomy is completed, I'm sure she will have a follow up appointment with an oncologist which will discuss her options.
Hi Ginger,
You mentioned that you do not take any medication. Since you indicated you had estrogen-receptor positive BC, I'm wondering if tamoxifen was recommended for you? With it, it has been found that there is a reduction in the rate of relapse of the original cancer, and also a 50% reduction in the risk of developing a new estrogen-receptor positive breast cancer. (Although you had bilateral mastectomies, there can still be at least some remaining breast tissue.
My brother was diagnosed to have Stage III Breast Cancer..he underwent Modified Radical Mastectomy & his histopath results showed positive ER/PR/Her2Neu...what exactly does triple positive test results mean in lay man's term? ESTROGEN RECEPTOR ASSAY = POSITIVE, STAINING INTENSITY=+2, PERCENT TUMOR CELLS STAINED=+5, PROGESTERONE RECEPTOR ASSAY=POSITIVE, STAINING INTENSITY=+3, PERCENT TUMOR CELLS STAINED=+4, c-erb-B2 (Her-2/neu) =POSITIVE...
Estrogen receptors and Progesterone receptors are often lumped into one category and if positive place the breast cancer into the category of hormone receptor positive breast cancer. This means that hormone therapy (the exact drug depends on the individual situation) will likely be recommended as part of the treatment plan. A Her-2 rating of 2+ suggests that the testing for this protein was done with a method called immunohistochemistry.
Dear river1980, Both Femara (letrozole) and Arimidex (anastrozole) are aromatase inhibitors used in the treatment of hormone receptor positive breast cancer in post menopausal women. Aromatase inhibitors block the enzyme aromatase (found in the body's muscle, skin, breast and fat), which is used to convert androgens (hormones produced by the adrenal glands) into estrogen. In the absence of estrogen, tumors dependent on this hormone for growth will shrink.
Hi. ER means "Estrogen Receptor" and PR means "Progesterone Receptor". ER/PR refers to the amount of hormone receptors found on the surface of cancer cells which your breast cancer has. Having a lot of these receptors (or a positive ER/PR) indicates that the cancer is hormone-sensitive and would benefit from treatment which would counteract the effects of estrogen stimulation.
Hepatic expression of estrogen receptor (ER)? was increased by estrogen exposure. In HepG2 cells, upregulation of ER? reduced HBV transcription, which required a specific region within enhancer I. Direct DNA-binding of ER? and histone deacetylase activity were not required for ERa-mediated repression of HBV genes. Overexpression of hepatocyte nuclear factor (HNF)4?, which binds to this region, overcame the repressive effect of ER?. ER?
Hi,
The issue with soy is that it contains chemicals that are very similar to estrogens. If the breast cancer is estrogen receptor positive, some of the treatments(Tamoxifen and others)) that are given work by blocking estrogen production. By ingesting other estrogens, there is a theoretical concern that a person could be interfering with the therapeutic effect of reducing estrogen and, in fact, give the tumor the food it needs to grow.
For patients with functioning ovaries which produces estrogen, the best strategy is to block the estrogen receptor in the tumor. Aromatase inhibitors only block estrogen production in the adrenal glands and these drugs will not be of benefit for patients with still functioning ovaries (since these drugs will not suppress ovarian estrogen production).
And with hormone positive cancer you for sure want to block your ovaries (if you still have them) and/or your adrenals from feeding estrogen to your estrogen positive breast cancer. You mention one mastectomy. That means you still have breast tissue on the remaining breast and also whatever breast tissue cells left behind on the mastectomy side. Research research research!! Weigh the options and risk factors and decide what you can live with.
Furthermore estradiol and tamoxifen acting through the estrogen receptor normally down regulates the expression of HER2/ERBB2. However when the ratio of the coactivator AIB-3 exceeds that of the corepressor PAX2, the expression of HER2/ERBB2 is upregulated in the presence of tamoxifen leading to tamoxifen resistant breast cancer
Overexpression of the HER2 gene can be suppressed by the amplification of other genes and the use of the drug Herceptin.
I am on my first recurrence and had been on IV chemo for a solid year. I needed a break. My cancer is estrogen receptor positive, too, and also low grade. That means it is slow growing, so typical IV chemo isn't going to work for me (it's designed to kill cells that are splitting quickly...mine don't). Aromasin is the same kind of Aromatase Inhibitor that Tamoxifen is, however, there is a greater risk of blood clots with Tamoxifen.
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