ve also been on Vagifem for 2 years and love the effect, however, my last ultrasound showed a build up of the lining of my uterus, so now I need an endometrial biopsy. My doctor said it could be from the Vagifem which is
estrogen without progesterone. I just read the leaflet and it does say that if you have a uterus, you should discuss adding progesterone to your regimen to counteract the possibility of the vagifem causing this lining buildup.