Estrogen inhibitors

Common Questions and Answers about Estrogen inhibitors

cenestin

Avatar f tn t women be allowed to have a small amount of the weak estrogen estriol present in their body to offset problems caused by not having estrogen? Why must ALL the estrogen be destroyed y these drugs - seems like serious overkill in my opinion.
Avatar f tn s muscle, skin, breast and fat), which is used to convert androgens (hormones produced by the adrenal glands) into estrogen. In the absence of estrogen, tumors dependent on this hormone for growth will shrink. Both of these medications have similar FDA approved indications.
Avatar f tn tamoxifen; or with aromatase inhibitors like arimidex. For patients with functioning ovaries which produces estrogen, the best strategy is to block the estrogen receptor in the tumor. Aromatase inhibitors only block estrogen production in the adrenal glands and these drugs will not be of benefit for patients with still functioning ovaries (since these drugs will not suppress ovarian estrogen production).
492898 tn?1222243598 As you probably already know, Tamoxifen and the aromatase inhibitors work in differerent ways. Tamifxifen blocks the estrogen receptor in the breast, whereas aromatase inhibitors block an enzyme called aromatase and keep if from converting androgen into estrogen. (Postmenopausal women get most of their estrogen from that conversion process, while premenopausal women get most of their estrogen from their ovaries.
Avatar m tn The plant steroids in saw palmetto act on progesterone receptors, that causes a reduction in estrogen levels. According to the results of a large international trial published in the "Journal of Clinical Oncology" in April 2011, estrogen and progesterone receptor status is a predictive marker of early breast cancer and post-treatment relapse. As you get older your hormone levels decrease, and your fat cells in your body increases.
Avatar f tn I've had three cancers, all estrogen positive. I tried a few medications and I'm now on Aromasin, an estrogen inhibitor. I figure I'll try the Aromasin and see if it gives me more protection from a recurrence. It's the least debilitating of the aromatase inhibitors for me, but it does cause joint pain. It's in clinical trials right now for ovca, but I am NOT waiting for the results of the trial.
135691 tn?1271097123 It works differently than aromatase inhibitors. It blocks the body from using estrogen, where aromatase inhibitors keep the body from producing estrogen in the first place. I was not able to try Tamoxifen at all because it does carry a relatively high incidence of causing blood clots when compared to aromatase inhibitors.
Avatar n tn The estrogen positive result makes tamoxifen or aromatase inhibitors, which are both estrogen blockers, a good choice to follow up with after the chemo. You need to talk over all your options with your oncologist, who has all your test results and knows your general health and life situation better than I. If there is any way that we can support you, please post back and we will do all we can. I am thinking of you.
Avatar m tn Hi Guys, i'm basically 32, morbidly Obese, Height 5'7''/67inches, Weight 245 Pounds/110KG, Finally I went to see a renowned Endocrinologist of my City, he suggested me to do couple of blood tests, results are as below: ➢ Hemoglobin A1c (HbA1c) Test for Diabetes (Blood glucose) – 6.3 nmol/L = eAG of 134 ➢ 2-Hour Insulin Glucose Challenge Test Results: CPS-2HOURS (Cohas) = 5.06nmol/L Insulin (2HOURS) = >2089 pmol/L ➢ Insulin1 – 370 pmol/L ➢ CPS = 2.
107366 tn?1305680375 I have been on Aromasin for about 12 weeks. I took Femara for a short time back last fall, and again this spring. Are any of you on Aromasin, Femara, Tamoxifen, or Arimidex experiencing joint/bone pain? If so, do you find it getting worse the longer you are on it? I finally got off IV chemo in favor of taking AI's because IV chemo was doing too much damage and I needed a break. My cancer is highly estrogen positive so AI's seem to be the choice for me at the moment.
Avatar n tn Dear LeahSiegel: In cancer that is Estrogen Receptor positive, there are several ways to block the estrogen. In premenopausal women, tamoxifen is a commonly used drug. In postmenopausal women, aromatase inhibitors are generally preferred. A premenopausal women could be rendered postmenopausal in two ways: 1. Drugs that will stop ovarian function and 2. Removal of ovaries. There are pros and cons of either choice and often this boils down to personal preference.
Avatar f tn Hi, Even with a total hysterectomy,the body will still produce some estrogen which is effectively blocked with an aromatase inhibitor (such as arimidex,Femara etc). In one study, aromatase inhibitors were found to offer greater benefit than tamoxifen in Post- menopausal women.Tamoxifen blocks the estrogen especially to the breast tissue. This is an important distinction because aromatase inhibitors cannot be used in Pre- menopausal women.
Avatar m tn Hi Guys, i'm basically 32, morbidly Obese, Height 5'7''/67inches, Weight 245 Pounds/110KG, Finally I went to see a renowned Endocrinologist of my City, he suggested me to do couple of blood tests, results are as below: ➢ Hemoglobin A1c (HbA1c) Test for Diabetes (Blood glucose) – 6.3 nmol/L = eAG of 134 ➢ 2-Hour Insulin Glucose Challenge Test Results: CPS-2HOURS (Cohas) = 5.06nmol/L Insulin (2HOURS) = >2089 pmol/L ➢ Insulin1 – 370 pmol/L ➢ CPS = 2.
107366 tn?1305680375 I have been on Aromasin for about 12 weeks. I took Femara for a short time back last fall, and again this spring. Are any of you on Aromasin, Femara, Tamoxifen, or Arimidex experiencing joint/bone pain? If so, do you find it getting worse the longer you are on it? I finally got off IV chemo in favor of taking AI's because IV chemo was doing too much damage and I needed a break.
Avatar n tn I am estrogen and progest negative, her2 positive, stage one, grade 3 1cm tumor. What specific chemo cocktail should I be on please? How many of these chemos would I need?
Avatar n tn However, 11 years ago, I underwent a complete hysterectomy and had been on HRT which I immediately discontinued at the time of diagnosis of breast cancer. My question is , if I am incapable of producing ovarian estrogen and I do not take any form of HRT is it necessary to continue to take tamoxifen? Have there been studies of women who had estrogen positive breast cancer while on HRT due to hysterectomy and stopped their source of estrogen.
Avatar f tn s ability to use estrogen, while Aromatase Inhibitors reduce the amount of estrogen production in the body. Tomoxifen also carries a risk of blood clots that the others don't. If Tamoxifen didn't work, one of the others just might. One thing to keep in mind, though, is that in order to get an idea if it is working or not, you really need to give it 90 days. I'm not sure one month would be enough time to see accurate results.
Avatar n tn Exemestane (Aromasin) and similar drugs called aromatase inhibitors, will only work with women who have already undergone menopause. If you're in the reproductive age group, Tamoxifen is still your primary option for hormonal treatment. For post-menopausal women who have breast cancer, and are estrogen receptor (ER) or progesterone receptor (PR) positive, switching from Tamoxifen to Aromasin would confer an advantage in terms of reducing the risk of cancer recurrence.
Avatar m tn The ovaries produce estrogen and removing them will reduce the risk of recurrence. The body also produces estrogen on its own - through fat cells, actually. So that's my 2 cents. Good luck to you.
492898 tn?1222243598 I restarted the Tamoxifen, and I cannot tolerate the Aromatose Inhibitors. So my oncologist says he wants to add another hormone blocking drug that is in a completely different family and it is injected. (I think he said the onset is a little slow and I think what he said started with a T, or maybe a P) You guys have any ideas what this may be?
Avatar n tn Dear Denisa: Tamoxifen is a hormone therapy that blocks estrogen to breast tissue. It is the hormone that is recommended for women with ER/PR positive breast cancer who are premenopausal or postmenopausal. Arimidex (or other aromatase inhibitors) is another class of hormone therapy that also blocks estrogen to breast tissue but these drugs are only offered to women who are postmenopausal. Both tamoxifen and armidex only address the ER/PR status and do not have any impact on CerbB2.
Avatar m tn TCA agents are predominantly serotonin and/or norepinephrine reuptake inhibitors. Serotonin deficiency causes numerous symptoms but includes chronic pain (eg: headaches, backaches, fibromyalgia).