Estrogen in postmenopausal women

Common Questions and Answers about Estrogen in postmenopausal women

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Avatar f tn A study testing the safety of vaginal estrogen (Vagifem) for vaginal atrophy/dryness in woman on estrogen-blocking drugs such as tamoxifen 4. A study testing the safety of low dose estrogen to treat hot flahes and vaginal dryness in women on AIs However, a search for estrogen as a treatment for ERneg BC turned up no results. If you come across the study you referred to again, I'd really appreciate a reference or link to the information...
Avatar n tn Arimidex (or other aromatase inhibitors) is another class of hormone therapy that also blocks estrogen to breast tissue but these drugs are only offered to women who are postmenopausal. Both tamoxifen and armidex only address the ER/PR status and do not have any impact on CerbB2. There are medications available to address CerbB2 positivity in the US (trastuzumab (Herceptin) and Lapatinib (Tykerb).
Avatar n tn At 52, probably less than 10% of women with postmenopausal bleeding have uterine cancer. At age 85, about 75% of women with bleeding have cancer. It would be unusual for ovarian cancer to manifest as postmenopausal bleeding. It may be that your symptoms are related to some hormonal type of influence but hormones include thyroid, prolactin, in addition to estrogen.
Avatar n tn Hi: I forgot to include this question in my last post. I am postmenopausal (about a year and a half) & am scheduled for a complete hysterectomy. I read a lot about physical/emotion effects of hysterectomies on premenopausal women, but can't find any information about the physical and emotional effect on women who've already gone through menopause. Is there still some hormonal effect on 'p. m.' women?
Avatar f tn I am a 45 year old women who has been very active. I ran two half marathans in the past year. The most recent in May. In July I was diagnosed with DVT and PE. I am on Coumadin. I am having side effects which some doctors don't really recognize as side effect. However, there are many instances on discusson boards of people with the same side effects. They are headache, heart palpatations, light headedness, depression, not felling well, fatige.
Avatar f tn A recent study confirmed the long-term superior efficacy and safety of anastrozole (Arimidex) over tamoxifen as initial adjuvant therapy for postmenopausal women with hormone-sensitive early breast cancer. It is apparently considered likely that this would hold true for the other AIs, such as Aromasin, but if you wish, you could ask your doctor about the possibility of trying Arimidex in place of Aromasin. Best wishes...
Avatar f tn Some studies suggest that these lumps may be dependent upon estrogen, because they are common in premenopausal women,pregnant women and postmenopausal women taking estrogen. Limiting beverages or foods that contain caffeine,including coffee and chocolate can help shrink the lump and reduce the pain. Also evening primrose oil and vitamins E and C supplement, application of warm compresses to the breast and massaging with Castor oil could be very beneficial.
492898 tn?1222243598 Tamifxifen blocks the estrogen receptor in the breast, whereas aromatase inhibitors block an enzyme called aromatase and keep if from converting androgen into estrogen. (Postmenopausal women get most of their estrogen from that conversion process, while premenopausal women get most of their estrogen from their ovaries.) I can't speak as to anyone's experience with Aromasin (I'm sure others with post about that!), but, of course, side effects very from indivdual to individual.
Avatar f tn t women be allowed to have a small amount of the weak estrogen estriol present in their body to offset problems caused by not having estrogen? Why must ALL the estrogen be destroyed y these drugs - seems like serious overkill in my opinion.
Avatar n tn It is also approved for the extended adjuvant treatment of early stage breast cancer in postmenopausal women who are within three months of completion of five years of tamoxifen therapy. Side effects that are comparable between Femara and tamoxifen include night sweats, weight gain, nausea and tiredness. Side effects seen more often with tamoxifen versus Femara were hot flashes and vaginal bleeding. The benefits of FEMARA in clinical trials are based on 24 months of treatment.
Avatar n tn In cancer that is Estrogen Receptor positive, there are several ways to block the estrogen. In premenopausal women, tamoxifen is a commonly used drug. In postmenopausal women, aromatase inhibitors are generally preferred. A premenopausal women could be rendered postmenopausal in two ways: 1. Drugs that will stop ovarian function and 2. Removal of ovaries. There are pros and cons of either choice and often this boils down to personal preference.
161647 tn?1280608163 In that case the inhibitory action they exert is lost so the body continue to produce both Fsh and Lh in high amount and that is responsible for the hot flashes which women in menopause experience .however, the little estrogen you still see are not actually produce by the ovaries but come from pheripheral tissues eg fat and skin .l hope this is able to answer your question in a layman way.
Avatar n tn I totally agree with everything Maggie367 has said in her post above. A LOT of women have postmenopausal bleeding and it turns out to be nothing but, it warrants a check up with your doc to just be on the safe side. A lot of women also continue having "phantom period" symptoms, getting all of the PMS symptoms but, no periods. It's quite common actually. Do make an appointment with your doc.
Avatar f tn I was diagnosed with GCT a while ago and have had a TAH BSO for this reason. Last January I was diagnosed with DCIS and underwent a unilateral mastectomy. I now see my oncologist every four months. I had a discussion with him today that made me wonder if I was getting accurate treatment. I asked for him to draw my inhibins again because they keep rising and in January my inhibin B was up to 79. It's my understanding that in a postmenopausal woman, that level should be undetectable.
Avatar m tn After a systematic review of medical research on the subject, experts reported that adding an aromatase inhibitor -- a drug that reduces the amount of estrogen produced in the body -- has clearly been shown to reduce the number of tumor recurrences in postmenopausal women compared with the standard drug tamoxifen, which works by blocking the action of estrogen on cancer tumors that are estrogen-receptor positive.
Avatar n tn Tamoxifen is a selective estrogen receptor modulator, meaning that it targets estrogen in the breast independent of ovarian production of estrogen. However, if you have had your ovaries removed, then you would be postmenopausal and could possibly take an aromatase inhibitor instead of tamoxifen. Either way, if your breast cancer is hormone receptor positive, then hormone therapy would likely be recommended as the body does produce estrogen outside of the ovaries.
Avatar m tn And now a new study published in the New England Journal of Medicine seems to indicate that taking women off of HRT cuts their cancer risk – and fast. For years, drug companies have pushed synthetic HRT on women as a panacea for hot flashes and the other ills of postmenopausal life. But I've always been disconcerted with the fact that women risk cancer, stroke, and blood clots just to overcome periodic discomfort. The new study was conducted by UCLA oncologist Dr.
368396 tn?1391945302 Hello, Causes of post menopausal bleeding could be ovarian cyst, fibroids and endometriosis, diseases of pituitary gland, hormonal imbalance of estrogen and progesterone, thyroid hormone imbalance and cervical conditions like cervicitis, cervical polyps or benign or malignant growths of cervix. It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is based on the medical information provided.
Avatar m tn I'm a 59 y/o postmenopausal female that was recently diagnosed with osteoporosis with a T score of -3.2. Was sent to an endocrine doc and did several blood tests as well. The doc wanted to start me on hormone therapy and injections based on my bone density test. I was prescribed the estrogen Duavee 20 mg daily and Prolia 60 mg shots every 6 months. Has anyone had experience with Duavee or Prolia?
Avatar f tn Tamoxifen can be used by both premenopausal and postmenopausal women. In premenopausal women, tamoxifen will not make the patient menopausal. The ovaries will still continue to produce estrogen. This is where the role ovarian ablation plays. Ovarian ablation can be accomplished by ovarian irradiation, surgery, or use of gonadotropin hormone-releasing hormone (GnRH) and leutenizing hormone-releasing hormone (LHRH) agonists.
Avatar f tn I did a hormonal imbalance test and it turns out my estrogen level is at 203. The doctor told me to eat healthy, no carbs and no sugar. They also say irregular period is due to stress. I did my research stress leads to high estrogen. So I am guessing that is what causing it to be high. But I also read eating foods with lots of vitamins (ex. Selenium. Melatonin, vitamin b, magnesium, etc.) helps reduce it. But all this time I've been on a diet and I have been eating all of that.
Avatar n tn Are there any side effects, etc., long term in women who are postmenopausal? Had my ovaries out a week ago. Feel good but just wondering about what others have felt further on.
Avatar f tn It sounds like you have vaginal dryness and atrophy which is a common problem for postmenopausal women. As estrogen decreases, the vaginal tissues dry and atrophy. This causes pain like you described. When you have this condition, it does not matter how much lubrication you at the time of intercourse. Your tissues are so dry that they cut and bleed with any friction. Luckily, there is a remedy.
Avatar m tn The largest epidemiologic study of postmenopausal women reports a 34% increase in risk of breast cancer among women with the highest compared to lowest quartiles of circulating PRL levels. Best wishes...
1277082 tn?1344057820 Femara is a postmenopausal drug but when women with low estrogen or PCOS take it it triggers FSH to be released from your brain causing a follicle to mature and ovulate. It has less side effects than clomid. Also clomid increases your chances of developing breast cancer later in life where femara does not, And clomid does not pick a single follicle to mature it tries to mature many, so you may not ovulate with clomid and you might develop more cycts.