Estradiol vs estrogen

Common Questions and Answers about Estradiol vs estrogen

activella

Estradiol is the main estrogen produced from the ovaries. It is an 18 carbon chain. Sometimes another substance is attached to the "alkyl" group at carbon 3 to allow for different forms of administering the estrogen such as injectable versus oral. The valerate that I'm familiar with is an injectable estrogen. That would make it last longer than "normal" estradiol. But estrogen is estrogen. In comparable dosages, the effects and risks and benefits would be the same.
Yes I've had it clinically diagnosed and my labs showed hyperinsulinemia. My fasting insulin was 39 mU/L (6 - 22) and 2 hours after drinking glucose it was 184 (15 - 65). In my case high insulin suppresses my appetite. Increased appetite could also be a symptom though. Metformin is a cause of vitamin B12 deficiency actually come to think of it. I had estrogen deficiency but I did have my ovary removed so yeah lol. It took 4 months for the other ovary to take over.
Are dairy products a problem for people with breast cancer history or those currently in treatment for breast cancer, due to any estradiol/estrogen content in dairy? Does goat's milk have less estradiol/estrogen than cow's milk? This is a separate issue from the issue of synthetic growth hormones given to milk producing cows. (Goat's milk doesn't have those.) To avoid growth hormones in milk, one should use only organic skim milk. But what about the estrogen content in milk?
These extra fat cells are also little estrogen factories. So weight gain contributes to the estrogen dominance that causes so many symptoms during the early stages of peri menopause. Women approaching menopause (I believe in connection with thyroid problems) are particularly prone to becoming insulin resistant due to metabolic changes related to fluctuations in adrenal and thyroid secretions.
This has all been very hard on such an active person with little health problems. Mom had a total hysterectomy 8 years ago and is still on estradiol. Her family doctor recommended that since she is past the typical menopausal age and because of the recent problems that she stop the estrogen therapy. She went to her gynocologist and he was very against her stopping the estradiol and changed her from an oral dose to a patch.
I am fifty years old and my estrogen ( estradiol) levels are less than 50. ( I live in the UK by the way. I am not sure if we use the same units of measurements as the US. I cannot choose between them. If this paper is true then there is a true advantage of Femara. This discussion is related to <a href='/posts/show/261425'>Arimidex and weight gain</a>.
If you're in the reproductive age group, Tamoxifen is still your primary option for hormonal treatment. For post-menopausal women who have breast cancer, and are estrogen receptor (ER) or progesterone receptor (PR) positive, switching from Tamoxifen to Aromasin would confer an advantage in terms of reducing the risk of cancer recurrence. The most common side effects associated with Tamoxifen are hot flashes, vaginal dryness, nausea and weight gain.
I have been on estrogen replacement since my surgery in 1998. I still have moderate-severe hot flashes and they seem to be getting more intense with age. I switched from oral Premarin which covered me pretty well but I didn't want to be taking pills the rest of my life. Since then I have tried a variety of patches that are really not very effective on a regular basis and very expensive. At my age, what do you recommend. Is Premarin dangerous (risk of DVT).
I have been on Depo-Provera for two years and it seems that it would mask all the symptoms that are most likely to identify a cyst vs. a tumour. Do you know anything about how the two would look different in the presence of Depo-Provera?
Recent lab work showed a high estrogen level for being post menopausal, though fat does boost estrogen levels - Estradiol level 108, Follicle Stimulating Hormone 22.6 - so my doctor had me go in for a pelvic and transvaginal ultrasound to check the thickness of the vaginal wall to be on safe side. The thickness was normal, but it was found that I have bilateral ovarian cysts with one being slightly abnormal. So now I need to go in to see a gynecologist.
Are dairy products a problem for people who have, or have had, breast or other hormonal cancers, due to any estradiol/estrogen content in dairy? Does goat's milk have less estradiol/estrogen than cow's milk? This is a separate issue from the issue of synthetic growth hormones given to milk producing cows. (Goat's milk doesn't have those.) To avoid growth hormones in milk, one should use only organic skim milk. But what about the estrogen content in milk? Is that an issue?
Sometimes estrogen out of balance with the testosterone can cause cystic acne. Maybe an increase in estrogen preferably estradiol. I am so sorry you have had such a hard time. I hope things get better soon.
I am bio identical HRT cream (estradiol and prog). My free t4 cam back at 1.8 even though my tsh was only .7 (my doc does not supress my tsh due to symptoms). So my question is how can your t4 be high but your tsh still be normal? My doc thinks my symptoms are from the high t4 but with my estradiol being only 8 I think it is from the estradiol. Do you think lowering my synthroid a tad is going to make that much of a difference without changing my estradiol dose?
Hello, I took ACTIVELLA 0.5mg Estradiol & 0.1mg Norethindrone. Now I am changed to CLIMARA 0.025 mg Patch & PROMETRIUM 100 mg daily. Isn't that too big a dose compared to the previous 0.1 mg Norenthindrone: 100mg vs 0.1mg? I am concerned but don't want to second guess my doc right away. Appreciate your opinion.
Estraderm patch contains the natural estrogen - estradiol. The patch comes in various dosage strengths. There has been alot of controversy over the use of hormone replacement therapy and breast cancer risk. Estrogens are contraindicated in women with a history of breast cancer. There is a slight increased risk of breast cancer in women 50-70 years old who have used hormone replacement therapy (HRT)for greater than five years. Discuss with your doctor these risks vs.
17-beta estradiol, the most biologically active; estrone, a derivative of estradiol and the second most dominant estrogen; and estriol, a very short-acting estrogen and the least biologically active. The first misconception is that US Food and Drug Administration (FDA)-regulated drugs are not bioidentical. This is wrong. A long list of FDA-approved hormone products contain 17-beta estradiol and, therefore, are bioidentical.
I developed ovarian cysts and my estradiol stayed high. My oncologist felt the high estradiol was competing with the Tamoxifen and recommended either surgical or chemical removal of the ovaries. I chose chemical (Lupron) because I figured I was so close to menopause, why undergo surgery. After a year of Lupron shots I stopped them only to see the cysts return and my estradiol shoot back up. I went back on the Lupron for another year.
My onc gives me the three month depot. My estradiol level was 11 before receiving my second shot. With a lumpectomy and wide margins, what would be my reoccurrance and new primary rates? I am still debating a bilateral. So many years ahead to worry about it. Are most of the studies on lumpectomy done on POSTmenopausuals? Thanks so much for your expertise!!! Sorry for so many questions. They just seem to keep building up. Very difficult decisions and such a complex situation.
It is produced primarily in the ovaries, body fat, and breast. E2, Estradiol; Serves as the primarily active estrogen BEFORE menopause and is LOST at menopause when follicles are gone. It is produced primarily in the ovaries with some made from testosterone in the brain, breast, and muscle. E3, Estriol; A weak estrogen made by the placenta during pregnancy. There is only one progestin, Progesterone, which is converted to other progestins.
Got my blood results back...can't remember the # for FSH but it was in the menopause range and estradiol was<32. I will be 43 in the spring. My periods have been erratic since I got it back after my sons birth (when he was 15/16 mos. old, he's now almost 6). The day I got the blood drawn I was bleeding, after a 90 day cycle. I don't have a LOT of symptoms, but I am bothered by a few things. Absolutely no sex drive.
Do you think that because of the drop in hormones just before my period, it might be worth looking into to get somekind of estrogen cream or along those lines? In the meantime, I am looking forward to trying the things you suggested. I really hope it works. Thanks for taking the time for me. Take of you too!
My most recent LH result came back at 12 (range 14-96) and my FSH came back at 5 (range 5-22). I also have low levels of estradiol 386 (range 315-1828) and progesterone 4 (range 2.4-9.4), but high levels of testosterone 1.9 (female <2) and DHEAS 8.7 (range 2.68-9.23). My TSH was at 3.97 (range 0.35-5), FT4 18 (range 12-22) and FT3 4.7 (range 2.6-5.7). I am a 27 year old female who has never been on birth control.
(Vivelle or Climara patch are both bioidentical estradiol) is used, even though these hormones are made from soy or yams in a lab, the end result is something that the body sees as 'normal' to what you used to make in spades... thus keeping your levels of estrogen (since Premarin is estrogen only... Prempro is estrogen and progestin) stable during menopause. It is the fluctuations in hormones that can cause hot flashes, etc.
I have been seriously thinking about switching to the Estrace which has much more estradiol vs the weaker estrone. I am wondering if the biest just doesn't have enough estradiol to relieve the symptoms. I wonder if the compounding pharm can add more estradiol to the mix? I just want sooooommmmmmeeee sssllleeeeppppp!!!!!!!!!!!!!!!!!!!!!!!!!!! Glad to hear you are feeling better on the lower dose! Yes my compounding phar charges a huge consult fee. What a crock. I'm rather cranky today.
Are you asking about the OTC's or the FDA approved (Estradiol comes to mind)? There is no proof that they are safer or more efficacious. A lot of them are soy based, and guess what...soy has not been ruled out as a having breast cancer risks. There is a risk to HRT, definitely, but the dosages have been adjusted and doctors no longer put you on them for the rest of your life. Like everything else, it is a case of risk vs quality of life. My mood swings were so bad I was homicidal.
erythropoietin, VEGF, IGF, FGF, a molecule from the estrogen family (e.g., 17-#-estradiol, estrone, estriol, an estradiol derivative, estradiol valerate, estradiol cypionate, mestranol, quinestrol), a molecule from the progestin-family (e.g., progesterone, hydroxyprogesterone caroate, medroxyprogesterone acetate), a statin (e.g. Simvastatin, Atorvastatin), and an antidiabetic agent (e.g., Rosiglitazone).
Granulosa cell tumors often produce excessive hormones estrogen/testosterone, and symptoms related to hyperestrogenism/hypertestosteronisim are common. My wife had excessive bleeding after she stopped having her periods.My wife's Dr's in Sloan kettering in NYC said she also has nothing to worry about because they removed the ovary fully intact(which is imperative). Removing the ovary fully intact is an indication for possibly no further tumors will develop.
Then gradually have the estradiol mixed with the weaker estrogen and see if that works. One other thing. He asked me if I was under a lot of stress. I have been under a ton of stress and this situation is only compounding it. He said that stress binds the estrogen receptors and that may be why the biest isnt working. ok gotta get the stress under control!
So off I went - to the pharmacy, syrnge in hand. This guy does tons of advertising about his compounding and bios etc. So when I got there he said "well have we ever done a consult?" No of course not. So he gives me a whole packet of papers to fill out and tells me he will call me with his first available opening for a consult ($200 btw). I said Ok that is fine but WHAT DO I DO NOW??????
They talk to cells through specific receptors that are made for them. For example, bio-identical estradiol (a type of estrogen) in patch form, gel or cream (brand names: Estragel, Estradot, Tri-Est, Bi-Est) acts just like the estradiol our ovaries secrete into the bloodstream. However, bioidentical estradiol in pill form (brand names: Estrace, Tri-Est, Bi-Est) has the negative effect of increasing blood clots because it is not natural for estrogen to enter the bloodstream through the stomach.
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