Overall, estrogen is produced in the ovaries, adrenal glands
and fat tissues. More specifically, the
estradiol and estrone forms are produced in the ovaries, while estriol is produced by the placenta during pregnancy.
In women, estrogen circulates in the bloodstream and binds to estrogen receptors on cells in targeted tissues, affecting not only the breast and uterus, but also the brain, bone, liver, heart and other tissues.