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The MTHFR A1298C mutation affects an enzyme that inhibits the utilization of something that inhibits an important chemical, which is a cofactor in
neurotransmitter production, including serotonin, dopamine, melatonin, epinephrine, and norepinephrine.
It also plays a role in the production of nitric oxide. If you have the MTHFR A1298C mutation, you may be deficient in BH4, which may cause psychological or neurological problems, as well as cardiovascular disease.