For meds I have found that adding Zonegrann to my cocktail has done the trick to help control the skin sensitivity.
anxiety/depression I am on Zoloft, Strattera and Lyrica, for
Restless Legs, I am on, Requip.
Yes, it does seem like a lot to me also, but it works, and finally I get some relief.
Exercise, like the eliptical machine 30 minutes or so daily does wonders for my anxiety/muscle twitching and depression, really as strong as any drug I take.