Epinephrine and thyroid
Common Questions and Answers about Epinephrine and thyroid
epipen
I had to get stitches last night, and was given 5-6 shots of epinephrine and lidocane. I told the intake nurse I was taking synthroid (which I presume implies thyroid problems). I felt a little "unusual" afterward (pounding heart, feeling calm and detached..), and was googling the side effects of the shot.. an article said this:
"Additionally, epinephrine and lidocaine usually aren’t used in patients with thyroid disease, or disease of the kidneys or liver.
Relaxes the bladder
Dilates pupils
Increases perspiration Increases mental activity
Stress constricts most blood vessels but dilates those in heart/leg/arm muscles and over time can cause cardiovascular problems The main sympathetic neurotransmitter is called noradrenaline which is released a the nerve endings. The stress response also includes the activity of the adrenal, pituitary and thyroid glands.
I went to my family doctor and she check my thyroid. Those results came back good. So I asked her to check my epinephrine levels because it almost seems like i have too much adrenaline. Those results cam back slightly high so she referred me to an endocrinologist. She also put me on 50mg of metoprolol (beta blocker). This medicine worked really good in beginning but several months later I am starting to have high blood pressure and high heart rate.
Have you had your thyroid and those adrenal hormones: epinephrine, norepinephrine, metanephrine and normetanephrine levels checked? Do you have any additional symptoms that you think might be unrelated to menopause, such as shortness of breath with exertion?
Epinephrine is the a hormone and neurotransmiter. It is produced by the adrenal gland an is a "fight-or-flight catecholamine." So is norepinephrine. In biochemistry, the prefix "nor" means that norepinephrine is an analog of epinephrine.
They function quite differently in the body. epinephrine is most commonly thought of in terms of t effect on the sympathetic nervous system - increasing heart rate, increasing blood pressure, hyper alertness, etc.
It's the epinephrine in the anesthetic that causes the racing heart, etc. Next time you're at the dentist and you need/want an anesthetic ask for one WITHOUT epinephrine. The medication generally takes a little longer to "kick in" and wears off faster, but your dentist will work with you for maximum comfort.
This can be physical stress just as injury or mental stress. It changes your norepinephrine and epinephrine. If these are out of balance you can get anxiety and ill. Allergies as well effect you immune system. Environmental factors also affect the endocrine system. Such as pollution, lead and many other things. So it is a variety of things. Fatigue can also be caused by low TSH made by the thyroid.
s left after the epinephrine is spent, and normetanephrine, the inactive metabolite of norepinephrine, which they also measure).
But it sounds like from what you are saying that it doesn't block the emission of epinephrine, just the action it takes- I'd suggest if you don't hear quickly from your doctor you consult a knowledgeable pharmacist for their opinion.
I had a 2nd trimester miscarriage the day that I had a mole removed at my dermatologist. They used Epinephrine and Xylocaine and when we received the autopsy report it revealed that my baby was perfectly normal and healthy without chromosonal issues prior to him dieing in my womb that day. Has anyone experienced this or known anyone who has? I researched on the web and found many warnings about pregnant women receiving Lidocaine from the dentist but not what they gave me.
So far I always got eye drops without epinephrine/or something equal to epinephrine, but this last eye doctor did not want to use any drops at all. He examined my eyes without dialating them.
Hi,
It is a serotonin and nor epinephrine reuptake inhibitor. The name of the neurotransmitter is nor epinephrine it is different from epinephrine.
Most of the side effects occur during the period when one is taking the medication. But the important thing to remember is to follow the doctors instructions carefully. To reduce the incidence of side effects it is always started with a low dose and then it is gradually increased.
s the epinephrine that is in the lidocaine. You can ask your dentist to use an anesthetic without epinephrine, I have had tons of dental work and always ask for that. Dentist doesn't mind at all and I've never had any problems. It doesn't last as long but if you start to feel anything while they are working the dentist will just give you more. I have done fine with it.
The dentist prescribed Halcyon (which I took 1 hour before the appointment) saying it will relax me and make numbing easier and the non-epinephrine local anesthetic last longer. He gave me 2 shots of local on each side.
Afterwards, I felt slight pain at one of the injection places, no pain anywhere else. The next day, my face was swollen, and I still had just the slight pain from one of the injections. The swelling was just of the skin of my face, not inside my mouth, not on my lips.
About two years ago, I noticed my heart was racing and I was having heart palpitations that felt like a hard or skipped heartbeat. I learned I was hyperthyroid and had Grave's disease. I was put on Toprol 25 mg daily to hekp with my heart while I went on an anti-thyroid called PTU.
Several months ago, palpitations began appearing again. I got tests done it appeared my thyroid was not overproducing anymore. Once I reduced my antithyroid to compensate, the palpitations went away.
These nodules/cysts are very common (about 50% of people have them on US evalution) - only 5-10% are cancer. With the normal thyroid levels and no significant thyroid nodule, it appears the thyroid is not contributing to current overall symptoms. You've had the test for adrenal insufficiency. Would consider an autoimmune (rheumatology) evalution - but work with your internist to figure out the next step.
m wondering with my heart problem how dangerous is it to get a dose of epinephrine and how will that affect my heart? I had an epinephrine dose in the early nineties due to a breathing problem, but that was before I was diagnosed with the mvp and atrial misfire.
The lab tests were normal, although the dopamine and nor epinephrine levels are on high range of normal. Only thyroid tests were the Free T 4 and THS, both of which were normal. A brain MRI did not disclose anything of significance. Went to psychiatrist and psychologist and they feel it is physiological. I have been a guinea pig for a variety of medication which have not worked. Any suggestions or ideas? Perhaps a broader thyroid works up? Heavy metals test? Lyme disease?
t freak out and made no adjustments to thyroid meds. Sent me for arthritis testing due to continued high CRP and multiple joints with arthritis and previous surgeries. Made follow up for June. Arthritis testing: nothing came out to explain CRP levels, no lupus, etc...
June blood test at endo:
Cortisol 6 (reference 5-25)
ACTH 93 (Reference 0-56)
CRP 2.73 (Reference 0.02-1.10)
Now she sort of started going hmm. Order MRI of pituitary, which I had done. Came back as 4x3 mm microadenoma.
I have severe "white coat hypertension" which causes my BP to rise very high when going to the doctor. A Dentist told me a long time ago to always tell the dentist to give me a shot WITHOUT epinephrine. In the meantime I got on BP meds which controls my BP but when going to the doctor it still goes up, but not as bad as in the past.
Fortunately, we have good ways of dealing with IFIS, such as intraocular epinephrine, viscoelastics, and the Malyugin Ring pupil expander. A sign of potential trouble is if the pupil doesn't dilate well in the office; this frequently indicates a more severe IFIS problem will be encountered at surgery.
The doctors did blood work which they all said came back normal and also tsh and thyroid antibody test. My TSH came back they say as normal it was a 4.48. My thyroid peroxidase ab came back as 1226. My thyroglobulin was <20 which was normal. No one has been of much help about this they just shrug their shoulders. The only thing that seems to stop my throat swelling and blood pressure returning to normal is the epinephrine shots.
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