I took mtx orally for many years and switched to injections within the last two years, along with adding Enbrel
You need a good 3 to 6 months to determine if mtx is going to work
for you. I would guess that if you've experienced NO improvement at 5 months, it's time to start questioning your rheumatologist about adjusting dosage or changing meds. Placquenil never did anything for me, so maybe ask about dropping that and replacing it with either Humira or Enbrel.