I started Effexor XR about 4 days ago. So far it's been somewhat similar for the initial stage as other SSRI's, though maybe with a touch more anxiety. The last time I was on an SSRI (first time on an SNRI now), was a few months back.
I'm also taking .5mg of clonazepam, and 20mg of propanolol, along with the 75mg of Effexor XR. I take all of them once per day, in the morning when I wake up (my peak anxiety time).