Efavirenz bioavailability
Common Questions and Answers about Efavirenz bioavailability
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I have 20 years and I have HIV positive person. I drink medicines already 4 months. I use drugs Truvada and Efavirenz Teva. Please tell me how to code your disease treated? Whether you are at injection instead of pills?
Are there still any evidence of efavirenz teratogenicity in human studies especially on the neuro tube defect
Atorvastatin is supposed to be one of the two most effective statins in lowing cholesterol so you are on a good one. Bioavailability is how well a med is absorbed and used by the body and bioavailability varies among the statins. It's actually a desired thing. The liver is the target organ so if it is slowed down in the liver (where this happens), it's in the target organ. But honestly, that is hard for me to understand.
1 hours ago I had protected sex with a sex worker which ended with a failed condom(punched) and then hour later i went to consult doctor and he prescribed EFAVIRENZ and LAMZID.AM I STIL SAFE?
Since that time, he is receiving HAART with lamivudine-zidovudine-efavirenz twice daily, but he told me that there are some days ( at maximun 3) that he does not take the pills, but most days of the month he is adhering to the treatment. His current viral load is 39,000 copies/ml.
When I realized of him diagnosis, I went to a doctor who gave me profilaxis about 18 hours post-exposure with lamivudine-zidovudine.
Although a standard meal did not affect ribavirin bioavailability (F1), administration of ribavirin with a high-fat meal increased bioavailability by 46% relative to the fasting state. A high-fat meal prolonged the duration of the zero-order input part of the absorption model, with D1 increasing from 0.498 h (fasting and standard meal) to 0.740 h. The type of meal also influenced the first-order input part of the absorption model (Table 1).
I am an HIV + male. 43 on truvada/ efavirenz for 2 year with a count of minus 20(undetectable). I was penetrated twice last week where the condom broke and was NOT replaced. The "top" partner is aware of my hiv status. What are the chances of infection for him and apart from testing what should be done? I am otherwise very healthy, no cuts, blood or aparent bruising was detected. I am freaking out for him.
My doctor recently put me on a combination of drugs for PEP, the drugs are lamzid and efavirenz and have very serious side effects. My exposure was licking/sucking a nipple of a non-pregnant HIV positive person. No milk came or blood came out but just had an after taste in my mouth. The act was for 2-3 seconds. What are my chances of getting HIV and are the reported cases of infection in adults, cause I know with babies you can.
When a medication is administered intravenously, its bioavailability is 100%. However, when a medication is administered orally, its bioavailability decreases because not all of it is absorbed. So 70% bioavailability means that, from the dose you took, 70% of it reached systemic circulation.
"Two studies have been carried out to assess the effect of food (ie, a high-fat breakfast) on the bioavailability of a SINGLE oral dose of ribavirin. An initial study by ICN Pharmaceuticals, Inc.
Also as a side note, Opana oral bioavailability is actually very low. Lower than morphine I believe the bioavailability is around 10 percent. However, if you reach your optimal dose, bioavailability matters little.
I see that this post is from October 2011. But since I have this typed, I'll post anyway :) Good luck and gentle hugs.
Welcome to the forum. Thanks for your question.
Since you are under care with PEP drugs, that doctor or clinic really ought to be the primary source of information about your risk, follow-up plans, etc. Therefore, my comments are brief.
Based on HIV infected persons' sexual histories of when and how they were infected, a CDC study calculated a risk of 1 HIV infection for every 10,000 episodes or performing fellatio on infected partners.
m now under retro-viral treatment (Abacavir, 3TC Lamiduvina, and Efavirenz TM as known in my country), healthy, fit, high CD4 count, undetectable viral load. Recently, I met a person, we kissed and we practiced oral sex on each other. Eventhough I know my condition, and have always tried to avoid people practice fellation on me, he insisted and at the end I agreed. Now, I am really concerned about him. Could he have been infected? Should I tell him to test for HIV?
Blood tests are not accurate for testing the active bioavailability of sex hormones in the cells and tissues. They only test what's in the blood stream. They aren't accurate for testing when a patient is using bioidentical topical creams. I've had two holistic doctors tell me this and have read numerous articles about which testing is correct depending on which type of hormones you're taking.
The ascorbate in Ferrous Ascorbate helps retardation or prevention of Fe(II) oxidation by ascorbate and to the existence of Fe(II) as a chelate with ascorbate ( vitamin C if you like ). Ferrous Ascrorbate will have a better bioavailability but you can add a vitamin C and vitamins B complex with sodium feredetate and have pretty good results.
Depending on your needs; are you lacking iron? anemia?
Hi all,
I have been on a combination of PEP drugs for the past week, the drugs are lamzid and efavirenz. 2 days after taking the drugs I started growing ulcers on my mouth (which has happened before) and I think one in my anus. Could this mean that I am HIV positive? I am very scared. My exposure was sucking a nipple of a woman for less than 2 seconds.
On AUGUST 19TH and AUGUST 20TH, I started taking ARVs which doctor prescribed. (Tenofovir disoproxil fumarate 300mg, Lamivudine USP 600mg, Efavirenz USP 200mg). ARVs made me dizzy, so I stoppped on AUGUST 21ST and AUGUST 22ND. After the viral load result, I started ARVs again. One pill everyday regularly.
4. On AUGUST 29th, I gave blood sample for PCR-HIV QUALITATIVE: (Performed using the Roche COBAS Ampliprep/COBAS Taqman HIV-1 Qualitative Version 2.0 assay.) It turned out negative.
The component of the final population pharmacokinetic model that describes the absorption phase is complex. Although a standard meal did not affect ribavirin bioavailability (F1), administration of ribavirin with a high-fat meal increased bioavailability by 46% relative to the fasting state. A high-fat meal prolonged the duration of the zero-order input part of the absorption model, with D1 increasing from 0.498 h (fasting and standard meal) to 0.740 h.
I was given pep (efavirenz+ tenofovir + lamivudine) for 28 days after 48 hours. But I had it for 29 days instead. Now after 57 days I am having flu like symptoms. Runny nose and a bit of sore throat. No fever though. And my abdominal hurts a bit and a little joint pain..
1. What are my chances of contracting hiv from this fingering exposure?
2. Is pep successful if taken at 48 hours of exposure.?
3. Do i need testing? I was tested negative at baseline.
They took my blood test only as a ground zero (for later comparisons). Then doctor prescribed me Zilarvir (2 tablets a day) and Efavirenz (1 tablet a day) to take them one (1) month. The medicines arrived at 15:00 (3:00 PM) and I took both - 17 hours after the incident and high risk exposure.
Doctor told me to come after one month when they will take a new blood test and follow-up.
I am on 300 mg of lamivudine (1 time before bed) 600 mg of efavirenz (1 time before bed) and 300 mg tenofovir (1 time before bed), How effective this for PEP? I am not sure coz I went for an emergency ward which may not have expert on HIV infection. Also I read the label it said for PEP purpouse lamivudine should be used as 150 mg twice daily. Am I right?
After 29 hours of exposure, I took Zifam Eletec (Tenofovir Disoproxil Fumarate 300mg+Lamivudine 300mg+Efavirenz 600mg) and I had been taking it regularly at the same exact time every day (30 days course) which ended on Jan 27, 2022.
1. For my case, may I know the HIV infection risk/possibility for my exposure (because the HIV status of that female is unknown and contact time is short)?
2.
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