Some people may retain the ability to walk without assistance, but others eventually require wheelchairs, canes, or other assistive devices
The NINDS conducts a broad range of
research on neuromuscular
disorders such as PLS. This
research is aimed at developing techniques to diagnose, treat, prevent, and ultimately cure these devastating diseases.
Hope this helps you
Refer http://www.ninds.nih.gov/disorders/primary_lateral_sclerosis/primary_lateral_sclerosis.