Duragesic janssen

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duragesic

475555 tn?1469304339 This could mean the trial is limited to certain countries like Ireland,and ?? and hasn't been listed yet? at clinicaltrials.gov CORK, Ireland, April 2, 2014 /PRNewswire/ -- Janssen R&D Ireland (Janssen) announced today that two Phase 3 trials are recruiting patients to examine the efficacy and safety of the NS3/4A protease inhibitor simeprevir in combination with the nucleotide inhibitor sofosbuvir for the treatment of chronic genotype 1 hepatitis C virus http://www.prnewswire.
Avatar f tn I found this, not sure of the accuracy of the whole article, but copied it for you. I've never used the patches, but this seems like very good info. Perhaps someone else can comment on the accuracy. --------------------------------------------------------------------------------------------------------------- The recommended procedure is to clean the area with water and then apply the patch. However, for anyone who has used Fentanyl Generics or Duragesic, we know that's ridiculous.
Avatar m tn I HAVE BEEN ON DURAGESIC FOR 6 YEARS, I WAS AT 100 4 MONTHS AGO THEN DRPPED IT TO 75 AND NOW AFTER 3-4 MONTHS I AM ON 50MCH PATCH... I CAN'T WAIT TO GET OFF THIS POISON.. ITS BEEN A 6 YEAR NIGHTMARE AND I AM DOING EVERYTHING I CAN TO MAKE IT END.. HAVE A HIP PROBLEM AND USED IT TO BUY MORE TIME UNTIL TOTAL REPLACEMENT.. THIS PATCH HAS BECOME MY WORSE DISABILITY.. ANYONE KNOW OF A DETOX OR WEAN OFF DRUG FOM HERE.. THE DROP ON THESE PATCHES ARE HORRIBLE..
Avatar m tn Food and Drug Administration (FDA) has granted Priority Review to the New Drug Application (NDA) by Janssen for simeprevir (TMC435), an investigational NS3/4A protease inhibitor administered as a 150 mg capsule once daily with pegylated interferon and ribavirin for the treatment of genotype 1 chronic hepatitis C in adult patients with compensated liver disease.
Avatar n tn Using damaged or cut DURAGESIC® patches can lead to the rapid release of the contents of the DURAGESIC® patch and absorption of a potentially fatal dose of fentanyl. I once walked in a room as a nurse, found a patient who had taken off his patch and chewed it...he coded and died...there is alot of medication concentrated in the patch to be released over a 24 hour period...not all at once...if you cut them you would have no way of knowing the amount your wife would be absorbing..
Avatar m tn Sense Simeprevir is another PI with about the same results as the other 2 I'm not sure a doctor would even recommend a prior failure even attempt it. Besides that it seems to be interferon just doesn't work for you. If it was me and I needed to treat right away I would ask about going off label and treat all oral using both of them, Sofo and simeprevir.
Avatar f tn I've been on the Duragesic 100 for almost 18 years. I've had 3 cervical fusions & 1 lumbar laminectomy. The Duragesic 100 has controlled my constant, chronic pain & while I've never been pain free, the Duragesic certainty helped. However in the last 2 months, its as if the patches are no longer working. I've always had additional breakthrough meds, but now its as if I'm going through withdrawals.
Avatar m tn Wow this is indeed great news and the fact that they partnered with Janssen... I may be asking some more questions on if I qualify for this soon!
Avatar m tn 22, 2013 /PRNewswire/ -- Janssen Therapeutics, Division of Janssen Products, LP (Janssen), announced today the U.S. Food and Drug Administration (FDA) has approved OLYSIO™ (simeprevir), an NS3/4A protease inhibitor, for the treatment of chronic hepatitis C infection as part of an antiviral treatment regimen in combination with pegylated interferon and ribavirin in genotype 1 infected adults with compensated liver disease, including cirrhosis.
Avatar m tn ARWR) collaborator Janssen Pharmaceuticals, Inc., one of the Janssen Pharmaceutical Companies of Johnson & Johnson, presented clinical data from REEF-1, a Phase 2b study of different combination regimens, including JNJ-73763989 (JNJ-3989), formerly called ARO-HBV, and/or JNJ-56136379 (JNJ-6379), and a nucleos(t)ide analog (NA) for the treatment of chronic hepatitis B virus infection (CHB).
Avatar m tn Always nice to hear when a new medicine comes out for this problem we have Medivir AB (OMX: MVIR) today reports that Janssen Pharmaceutical R&D Ireland (Janssen) has been informed by the Japanese Ministry of Health, Labour and Welfare (MHLW) that simeprevir has been approved for the treatment of genotype 1 chronic hepatitis C virus (HCV) infection. "The approval in Japan is a very important step in providing patients with new treatment options.
Avatar m tn ), a leading RNA medicines company, announced today that preclinical data for a multi-siRNA treatment of Chronic Hepatitis B Virus (HBV), developed in collaboration with Janssen Pharmaceuticals, Inc., part of the Janssen Pharmaceutical Companies of Johnson & Johnson, will be presented in a poster at The Liver Meeting, the 67th Annual Meeting of the American Association for the Study of Liver Disease (AASLD) being held November 11-15, 2016, in Boston.
Avatar m tn I have chronic pain from Tarlov Disease and Interstial Cystitis. My pain has been well managed for 2 1/2 years using tramadol (ultram) for maintenance and lortab for break through pain. I have developed chronic kidney disease and my doctors are pushing me to get some exercise. I have found that with every exercise form I have tried I quickly get beyond the pain control offered bu tramadol and lortab so i can't exercise.
Avatar n tn I have been on the Duragesic Patch 74 mcg for about 3 1/2 years. During the last 6 months, I have become extremely depressed. I notice that it is worse after the second day any given patch is on. I have been treated for the depression with different antidepressants and so far have not found one that works. I am so desperate for help as the depression has taken over my life. Has anyone out there experienced this? Any input would be appreciated. I feel as though I am running out of time.
179856 tn?1333547362 The notes are secured by $155 million in success-based payments that Vertex is eligible to receive from Janssen Pharmaceutica. The milestones are linked to filing, approval, and launch of telaprevir in Europe. Separately, Vertex will receive roughly $35 million in cash for the sale of rights to an additional $95 million in future milestone fees tied only to the launch of telaprevir in Europe.
Avatar f tn m not a doctor), but I would think that if you are on duragesic (the most powerful painkiller on the planet), you don't have to take the solpadeine, and, if the amitriptyline is just to help you sleep, you probably don't need it, either, if you find the duragesic to be sedating. And in fact, you might not need the lyrica. Of course, that's assuming you are getting them all from one doctor. If you have more than one doctor, make sure they *all* know what you are taking.
Avatar m tn there had me on a medication called Temgesic. When I came back to usa I went on Duragesic Patch after a year or so.. I think this Temgesic is the detox meds you guys are talking about. I have a old box here and they were 2mg sublingal. Its buprenorfina (sp).. Brand as I say was Temgesic. Its a great medication for pain and I can never remember having the side effect of it that I have with this patch. I can't wait for the day I have none of this medication in my body.
Avatar n tn I guess what I am looking for here is some feedback from those who have transitioned from duragesic into oral meds. See, I am alone and doing all of this alone is a scary road. Thank you folks...any questions, please feel free.
Avatar n tn Hello again....I did get to my pain management Dr. this week and talked about the Duragesic Patch being partially responsible for this severe depression I am in. Of course they don't have a crystal ball but discussed switching me into another medication and spoke of the conversion table they use to determine what dose to use. My question is this....