Interferon Gamma can degrade cccDNA inside hepatocytes without killing the
cells. HBV specific Cytotoxic T
cells can
kill an infected liver cell, and NK
cells can also kill any infected cells.
"What is the percentage of infected hepatocytes in a hbv patient? "
During acute infection, it can be up to 100%.
"Generating antibodies again hbsag are not just sufficient."
Because there are far more Sub Viral Particles and Dane Particles, both have HBsAg coat, than HBsAb.