Dosing enoxaparin in obese patients

Common Questions and Answers about Dosing enoxaparin in obese patients

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Avatar n tn In one study, 50 women with thrombophilia (including 20 factor V Leiden heterozygotes) and recurrent pregnancy loss were treated with enoxaparin throughout 61 subsequent pregnancies. The live birth rate was 75% with enoxaparin prophylaxis, compared to 20% in prior untreated pregnancies [Brenner et al 2000].
Avatar n tn On the 22nd post-operative day, due to severe pain in the epigastric zone, her doctor ordered an abdominal CT. It turns out that portal vein and superior mesenteric vein are thrombosed. They put her on enoxaparin and wanted her to rest for 5 days until the next control. She refused to be put on heparin or warfarin because of her history of gastrointestinal bleeding and recent surgery. We've been told thrombectomy would be extremely risky, given her medical history.
Avatar m tn I am 27 weeks pregnancy and have dvt, start to using CLEXANE(ENOXAPARIN) I am really worried is there any harm to my baby Thanks & Rgards
Avatar f tn Of note is that in the BOC trial, SVR rates in patients managed by RBV dose reduction alone were comparable to those in patients managed with erythropoietin therapy.23 Similarly, in the TVR trials, dose reduction of RBV had no effect on SVR rates, and therefore dose reduction should be the initial response to management of anemia.
Avatar m tn SBPH), a clinical-stage biopharmaceutical company developing novel therapeutics for the treatment of viral infections, inflammatory diseases and cancer, today announced that it has begun dosing the first cohort of patients in the ACHIEVE global Phase 2 clinical program evaluating SB 9200 in immuno-active, treatment-naïve HBV patients without cirrhosis.
Avatar m tn 7 compared with those with genotype 1, cirrhotic patients had an OR of 0.15 compared with noncirrhotic patients, and obese patients had an OR of 0.23 compared with normal and overweight patients. Hepatic steatosis was not an independent risk factor for response to antiviral treatment. In conclusion, obesity, only when defined as a BMI greater than 30 kg/m(2), is an independent (of genotype and cirrhosis) negative predictor of response to hepatitis C treatment. Retrieved from http://www.ncbi.
Avatar n tn Hello, I have been reading a lot lately about the side effects of Seroquel. The one that concerns me the most is the diabetes. I am obese and diabetes runs in my family. I even have a brother that is insulin dependent. I am wondering if I should get off this drug? Does the diabetes continue even after the drug is discontinued? Is there another antipsychotic I could take that does not have this side effect? Thank you so much for your time.
Avatar f tn I wad injecting in the stomach but started developing scar tissue and it was getting sorer and sorer.
Avatar f tn Blood oxygen levels are not a botheration at this time but you should concentrate on losing some weight. Weight reduction, if you are overweight or obese, is the optimal health strategy for patients who suffer from COPD. This can be done through a combination of diet, an increase in physical activity and sometimes medication. Weight reduction can help reduce dyspnea, increase exercise tolerance and improve your quality of life.
Avatar n tn The problem becomes more evident in some patient categories, such as obese patients, those with chronic bronchopneumopathy or those patients in intensive care, for which for various reasons the acoustic window is suboptimal.
Avatar n tn continue through with warfarin, or to stop the warfarin and bridge in between with enoxaparin or heparin (as snconorm had done). http://www.circ.ahajournals.org/cgi/content/full/116/22/2531 So continuing through with warfarin seems to be the newer strategy. What would NOT be done is to stop anticoagulation altogether.
Avatar f tn The safety and effectiveness of these dosing interval adjustment recommendations have not been clinically evaluated in patients with moderate or severe renal impairment, therefore 5 6 clinical response to treatment and renal function should be closely monitored in these patients [See Warnings and Precautions (5.3)]. There are no data to recommend use of VIREAD tablets 150, 200 or 250 mg or VIREAD oral powder in patients with renal impairment.
Avatar n tn That depends on your doctors comfort levels in prescribing , a patients ability to tolerate side effects, other medical conditions, effectiveness of using opiates, but typically- most physicians will not prescribe over 90 to 100 MME mg dosing per day-(Morphine equivalent dosing per day)- and typically only for patients who have been on opiates for some time. MME dosing combines both long acting and immediate release types of opiates to reach 90-100mg MME daily.
9648 tn?1290091207 2 mg/kg were compared with those with a dose /=13.2 mg/kg (n=84) showed a relapse rate of 19.0% in contrast to 71.4% in patients with a ribavirin dose of /=13.2 mg/kg ribavirin dosed group (59.5% versus 28.6%). Conclusions. Weight-adapted ribavirin dosing in combination with peg-IFN alfa-2a to avoid giving low doses of ribavirin should be evaluated. This will minimize relapse, especially in HCV GT 1 patients.
Avatar m tn Preliminary pharmacokinetic analyses of pre-dose samples taken on day 8 of dosing in approximately 50 patients in this study indicate that trough concentrations in those patients receiving a twice-daily dosing schedule are similar to trough concentrations of a three times daily dosing schedule, and are also similar to trough concentrations observed in PROVE 1 and PROVE 2.
Avatar m tn Obese patients usually are encouraged to lose weight before having surgery. Although weight loss alone is not likely to solve the problem, it can make complications during and after surgery less likely. Weight loss and nutritional counseling can help patients before and after surgery. Psychological counseling: Mental health professionals may address issues such as depression, sexual dysfunction, and low self-esteem.
Avatar f tn Even though it has not yet been approved, Dr Eliot Godofsky, infectious disease specialist, University Hepatitis Center, Bradenton, Florida, has already been using the BID regimen in patients where it was thought the Incivek TID regimen would not work. Patients have reported less diarrhea when on the BID regimen, he added, speculating it may be due to the requirement of taking Incivek with a fatty meal.
Avatar m tn On the day before administration of the next dose, peginterferon--2b was undetectable in nine patients in group A (once weekly dosing). The same pattern was observed during the next 3 weeks of therapy. In group B (twice weekly dosing) peginterferon--2b was detectable at any given time point and higher than in group A (P between 0.01 and <0.0001). Viral load decreased in all patients within 2 days after the first dose of peginterferon--2b, but increased again on day 3.
Avatar m tn In a Phase IIa combination trial in HCV patients, we reported data that showed that setrobuvir added to pegylated interferon and ribavirin accelerated the rate of viral clearance, with comparable response at setrobuvir doses of 200 mg bid and 400 mg bid. A single patient out of more than 60 exhibited viral breakthrough while receiving setrobuvir plus standard of care, corresponding to a low breakthrough rate of < 2%.
Avatar f tn Yes I'm on the generic enoxaparin. I was on it with my first and forth (all 4 pregnancies were miscarriages). Now I'm on it again since 3 1/2 weeks pregnant.
Avatar f tn The authors also suggested that use of higher doses of pegylated interferon and ribavirin for extended periods might help overcome the lower response rates observed in obese patients. Weight-based dosing and longer treatment durations are currently the subject of considerable research, but the authors also suggested higher dosing based on levels of insulin resistance or amount of visceral fat, rather than body weight alone.
Avatar f tn I am 30 weeks pregnant. In the last pregnancy (2007), I had still birth at 34 weeks due to IUGR. During the present pregnancy, my doctor has recommended aspirin and Low Molecular Weight Heparin (like Clexane) for the entire pregnancy period. I am regularly taking these both medicines. Regularly undergoing Ultrasound regular scan and Doppler scan. Till now the growth of fetus is good and is better than the last pregnancy. But my platelet count is coming down, now its around 160,000.
Avatar f tn Likewise, ultrasound in obese patients is not nearly as accurate in diagnosing fatty liver as it is in normal weight individuals. Your liver enzymes are really not that far out of range that you should panic or anything like that but they do suggest some ongoing damage which should be diagnosed with as much certainty as possible. You said you saw a "specialist' who told you because you're extremely obese you obviously have fatty liver. What type of specialist was this doctor?
Avatar f tn No safety or efficacy data are available in patients with renal impairment who received VIREAD using these dosing guidelines, so the potential benefit of VIREAD therapy should be assessed against the potential risk of renal toxicity. VIREAD should be avoided with concurrent or recent use of a nephrotoxic agent.
Avatar m tn In general, acetaminophen at reduced dosing is a safe option. In patients with cirrhosis, nonsteroidal anti-inflammatory drugs should be avoided to avert renal failure, and opiates should be avoided or used sparingly, with low and infrequent dosing, to prevent encephalopathy. ...The greater the progression of liver dysfunction, the greater the impairment in drug metabolism.