The most well tolerated initial treatment is the non-sedating antihistamine
Claritin. Zyrtec is similar but may sometimes cause sedation. If that does
n't eliminate the hives, a sedating-type of antihistamine (hydroxyzine, cyproheptadine or doxepin) is added at night. High doses may be needed and this will cause sedation. Fortunately, most patients will become less affected by sedation after they have taken the drug regularly for a while.