At about eight years follow-up, they found a possible biological interaction between the CFH Y402H genotype and intakes of zinc, β-carotene, lutein/zeaxanthin, and eicosapentaenoic/docosahexaenoic acid (
EPA/
DHA), and between the LOC387715 A69S genotype and zinc and
EPA/
DHA, based on significant synergy indices (P < .05 for all).