Now, what does lipstick have to do with HCV treatment, you may really wonder. It may sound odd, naturally, of couse. Well, it does have something to do with lipstick. Lipstick is how I found out about an irksome, little side effect. One day, as I was darting out of my place, I hurridly swiped lipstick across my lips, and as I did, I just mumbled "ouch" and said "that hurt." The first time it happened was toward the end of the first week.