Since I was a kid I've had this problem, used to be hyper, then in college developed Hashimoto's and have been hypo ever since. So, have been on Synthroid 20 plus years. Lingering symptoms include fatigue, memory issues, lack of concentration, hip joint pain. Have been diagnosed with CFS. I should correct the holistic statement, the doctor i'm seeing is an MD not a naturopath, but she is convinced that T4 does not work well for Hashimoto's.