Cyclosporine and pregnancy
Common Questions and Answers about Cyclosporine and pregnancy
restasis
About 6 months ago, I was finally diagnosed and started taking cyclosporine 100 mg 2x day. After a week, I could eat like a normal person—just about anything I wanted. It was great, it even allowed me to travel to Europe. The cyclosporine I was taking was a powder in a capsule, apparently this has been taken off the market and instead I took the same medication, but it was in the form of a capsule with alcohol. Unfortunately, after a short time, I was right back to before treatment.
Chronic urticaria, especially the autoimmune type, is often resistant to antihistamine treatment. They usually require immunosuppression and medications such as prednisone and cyclosporine may be given. There has been several studies already which have shown effectiveness in using cyclosporine in the treatment of chronic idiopathic urticaria, who fail to respond to conventional therapy (ref: http://www.e-ijd.org/article.asp?
Is there a correlation between taking less ursodiol and my through cyclosporine levels slightly decreasing? Could my lower cyclosporine levels have contributed to the lessening of my symptoms? Could taking less ursodiol have contributed to my diminishing symptoms. What would be the lest acceptable through cyclosporine level for a patient on mono -therapy four and one half years post transplant with no episodes of rejection? Thank you so very much Dr.
(interestingly though, a few days before at the vet, the schirmer test was 12 in both eyes). Now 6 weeks later, the right eye has a 6 and the left eye still has 0. The specialist reviewed all of the options with us - cyclosporine, pilocarpine or tacrolimus with sirolimus. She said that very rarely has she seen any dog respond to cyclosporine after not responding to tacrolimus.
i think this is a reasonable way of lowering the cyclosporine dose and as long as labs are being followed regularly i think that this is OK. I am not aware of rapa affecting bile flow.
Do you think it is neck pain or could it be an abdominal problem from being on pred, cyclosporine for 5 years (she has been on cyclosporine consistently for 5 years and pred on/off whenever she has a recurrence), coud it be cancer in her abdomen? I am thinking about going for a myelogram but what tests would you run else since her chemistry was pretty clean. Could it be pancreatitis even though her chemistry is clean? What are other causes for a dog crying?
For example, after each meal i now collapse with low BP when the blood rushes to the stomach to digest my food which i have had to deal with now for the past seven years and the anti rejection meds called cyclosporine have caused a lot of unpleasant 'mole like' crusty brown lesions on my torso which can be very itchy.
For the past 2 years, she has been on Cyclosporine and Ketaconazole and it has controlled her itching, scratching and yeast buildup. Unfortunately, it has contributed to her kidney problems. She has quickly moved to Stage 3 kidney disease. We originally attributed her failing kidney function to her food. We have been feeding her gluten free food because of her allergies, but they have a high protein and sometimes higher sodium and phosphorus content.
What happens is their eyes stop producing their own tears, and the eyes dry out and become very itchy and irritated. As a result, the skin around the eyes becomes red and inflamed looking, and it COULD have something to do with the redness and hair loss around the mouth as well, since these dogs have such short faces, the itchy eyes cause them to rub their faces on carpets, rough-textured furniture, etc., to seek relief from the itching.
She has been wearing the hood for 6 months to prevent her for scratching her eyes. She just turned 4 and and she is in so much pain, We finally decided to have surgery and have found out it is 2600.00 per eye. I am very worried it won't work. She just cannot enjoy her life ands she is so young. She is a shitzu-maltese mix, a wonderful little girl. I want to give her her life back. The specialist said there were no more options. The poor dog gets drops all day long and through the night.
In an additional 33 patients, glomerular and tubular NEP protein levels from renal graft biopsies were significantly higher among the 13 patients receiving cyclosporine + EC-MPS than among the 12 patients receiving cyclosporine + azathioprine or 8 patients receiving cyclosporine alone. Glomerular NEP expression inversely correlated with glomerulosclerosis and proteinuria, and tubular NEP expression inversely correlated with interstitial fibrosis.
We took her back to the vet, and still, after being on cyclosporine and antibiotics, no tear production, and there is still discharge. The vet seemed pretty worried (which only made me more nervous). She is referring us to an eye specialist, so hopefully we can get in soon!
I was switched to cyclosporine and Myfortic. When the Incivek was started my cyclosporine was dropped to 25 mg once per day due to their interaction. Due to my previous non-response and to the multiple variations of the HCV I carry my odds were considered to be about 30%, maybe 40% at best. At the end of week 4 the HCV RNA was not detectable. The only additional side effect is that the anemia came quicker this time. I will start Procrit injections probably sometime this week.
methylprednisolone and cyclosporine A treatment:
(1)cyclosporine A 50MG BID PO until 3.15
(2)methylprednisolone tablets 11.30 2.5# QD, 12.15 2# QD, 12.30 1.5# QD,
1.14 1# QD, 2.13 0.5# QD, 3.
t swelling and foamy urine. Now that I have a diagnosis, I am on pill forms of Prednisone every other day and Cyclosporine 2x every day. I have been on the meds for over 1 1/2 weeks and noticed that the foamy urine amount has doubled, my face swells unbelievably, and walking is difficult, as the bottom of my feet and ankles cause me severe pain. I checked with my Nephrologist and she states that it will take a little while for my body to adjust to the medicine.
How iron clad is the expiration date for cyclosporine eye drops for dogs?
Both my wife and I are on restasis (same med as you) for over 8 years with excellent results. Restasis is used twice per day but does not have to be used at bedtime. So put drops in morning and with your evening meal. Because of the cumlative effect of restasis the time between dosages is not critical as it is for antibiotics and heart medication. Remember it takes 6 months for your medication to fully kick in. During the day use preservative free artificial tears.
I think it would depend upon the type of symptoms one is having.
If it is a sleep disorder (RLS/PLMD) - I have found that Trazadone works well.
For neuropathy and other sensations I had relief with both Cymbalta and Lyrica. The only downside to the Lyrica was difficulty with cognition and drowsiness.
Savella (milnacipran) is the new medication and it works much the same as Cymbalta...it is an antidepressant.
As uk2 mentioned, the patches help with pain as well.
He gained 6 pounds in a little over a month and drank and ate constantly. The vet put him on Lysodren - - and very little! He only gets 1/4 of a 500 mg pill twice a week and he has already dropped the weight and eats less and doesnt drink quite as much.
One morning he had green gunk in one of his eyes and it was stuck together. I held him with a warm wet cloth over it and then it seemed OK.
He explained to me it was an autoimmune disorder and put me on Cyclosporine. I was wondering if I needed any kind of thyroid medicine?
He got large B-Cell Lymphoma at age 7 from his cyclosporine. He went through CHOP chemotherapy and has been on NO IMMO DRUGS and takes nothing for rejection for over 21 years. They both are the 3rd & 4th oldest living with their disease in the world.. hereditary tyrosinemia type I.. DONT PUT UP EXPIRATION ON LIVER TRANSPLANTS.. EVERYONE IS DIFFERENT AND MY SONS ARE AN EXAMPLE TO THAT.
They had me up his cyclosporine dose to 300mg a day and add in the ketoconazole as a stabalizer. After a week and a half of this he wasnt taking his pills willingly anymore and not eating or drinking much. I decided to reduce his pill intake, especially the cyclosporine to 100mg a day but kept using the ketoconazole. He started eating more and started taking his pills again. But still looked underweight. Now its three weeks after that visit.
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