You are taking very doses, but they certainly can be the cause of a lot of side effects.
The good news is your body generally can adapt, and
the drugs can remodel
the heart... at least they did for me. I eventually was taking 10mg of lisinopril and 50 mg of Coreg.
Headaches are definitely associated with drugs like Isosorbide (Imdur), angina meds like Ranexa and of course Nitro pills, especially if combined with alcohol.
I agree that you should report the problem to your doctor.