That actually causes the Therapeutic index also known as Therapeutic ratio TD/ED to decrease, which means that whereas the effective dose did in fact increase, the toxic dose may not have to the same
degree. Thus, a patient may need a much higher dose for pain control, yet still overdose none the less.
So, I would recommend you to be very cautious, no matter how tolerant you may think you are. Please let me know if you would like to get clean one day.