Dr. Charles Parker in his book, New ADHD Medication Rules, on page 118 talk about going over the top or too high a dosage. He says, "at the top you become more irritable, sometimes depressed, unfocused, or hyperfocused, lose your appetite, have difficulty sleeping well, or feel stoned." On page 119, " More symptoms at the Top: confusion, disorientatiion, forgetfulness intensifies, cognitive stress, anxiety each increased, while self-expression diminishes.