Clopidogrel metabolic pathway
Common Questions and Answers about Clopidogrel metabolic pathway
plavix
Clopidogrel (Plavix) is an anti-platelet agent and acts via a different mechanism than coumadin does (coagulation pathway). Adding Clopidogrel to aspirin is a guideline that holds a Class 2b (see below) recommendation, and usually considered in those in which Warfarin is unsuitable due to patient preference or physician's assessment on a patient's ability to safely sustain anticoagulation.
2. Weak recommendation: Benefits and risks closely balanced and/or uncertain
B.
In agreement with those studies we also find reduced mCMV growth in siRNA knock-down experiments targeting enzymes in the isoprenod biosynthesis pathway. These studies indicate the importance of the geranylgeranylation to viral replication. Although, it is worth noting that the isoprenoid biosynthesis pathway is highly complicated with multiple branch points involving redundant enzymatic steps, sharing of subunits, and competing reactions.
after a stent inplant how long must clopidogrel-winthrop be taken my heart attack was caused by cholestral which now a 3
Which is better anticoagulnt from rivaroxaban and clopidogrel for stroke prevention.My grandmother had stroke 6 years ago and she has atrial fibrilation.So far she used clopidogrel as treatment but her new doctor perscribed medication with rivaroxaban (but it is far more expensive) ?
If a patient has drug eluding stent (DES) implant it is recommended that plavix (clopidogrel) be prescribed up to a year to help prevent blood clots with the implant.
If one has A-fib there is a risk that blood clots can occur as blood may pool due to the very fast beat.
Information regarding the use of the 2 anti-platelet together can present a problem and the source is MedinceNet.com.
s heart valve and a pacemaker and they were taking the medication clopidogrel for 7 years and then stopped taking it for a few months, could there be any ramifications?
Without getting into the pharmocological aspects regarding the mechanism of action of asprin resistance and the mechanixm of activity of plavix (clopidogrel), the American Academy of Cardiology recommends tests.
Dr. Waksman:
"I'll try to do my best because it's a controversy.
After six years post MI and ef varying between 25-35%, my cardiologist now feels that I should shift from aspirin(150)+clopidogrel (75) to warfarin. Two years back he did tell me that he is double minded on whether to put me on warfarin. But this time he appears to be very sure and has insisted me to go for warfarin.
His justification is "that is what literature says".
I have no AF or valve problem.
New data show that when clopidogrel and omeprazole are taken together, the effectiveness of clopidogrel is reduced. Patients at risk for heart attacks or strokes who use clopidogrel to prevent blood clots will not get the full effect of this medicine if they are also taking omeprazole.
The only clinical thing I've seen says: "Interaction proposed due to common CYP450 metabolic pathway with methadone (Harrington et al. 1999)." Which if I got it right, means that neither drug is likely going to metabolize correctly or at a normal pace due to competition for a limited amount of available CYP450... which for must drugs equals unwanted side-effects or adverse reactions.
s like if I want some Clopidogrel (another form of anti platelet med) I could ask for either Clopidogrel or Plavix, Plavix is the brand name the drug company trades the medication under.
My father has gone thru angiplasy few months back and he started getting Red or purple spots on the skin. He is taking deplatt and atorvasatin. I heard this can be due to deplatt(Clopidogrel). Please let me know any treatment for the same . should we discontinue Clopidogrel. Is there any alternative for this medicine in india.
Ive only heard of proton pump inhibitors reducing the effect of Clopidogrel (plavix) but only by a tiny amount. I do have to question though if Zantac is a proton pump inhibitor anyway? Isn't it just a H2 receptor blocker?
ve had arthralgia ,oseaophigitis,rashes and chest pain .
In the CAPRIE trial, clopidogrel (plavix) was equivalent to aspirin for patients with a recent (but not acute) MI. Some subgroups of patients with cardiovascular disease in this trial seemed to benefit more from clopidogrel than from aspirin: those with a history of bypass surgery, a prior stroke or MI, arterial disease in two or more areas, diabetes, or high cholesterol. Clopidogrel may be a reasonable choice for these patients.
Evidence is available from retrospective analysis of the CPARIE trial with clopidogrel that patients who have atherosclerosis in other vascular beds, such as prior ischemic stroke or concurrent peripheral vascular disease, benefit from receiving clopidogrel over aspirin. Some cardiologists have concluded that these patients, who are at higher risk of a subsequent vascular event, would benefit from combined therapy.
Warfarin (coumadin): Because of the increased risk of bleeding, the concomitant administration of Warfarin with Plavix should be undertaken with caution. (See PRECAUTIONS - General.)
At high concentrations in vitro, clopidogrel inhibits P450 (C).
Hello; I have got one coronary DES stent implanted since two month ago ("Endeavor RESOLUTE RX"). I am on clopidogrel, aspirin, atorvastatin, carvedilol, enalapril and pantoprazol. Fearing about scars growing inside the stent's mesh, I have read that some people recommend vitamin E for cosmetic appearance of scars; well, my question is: Could vitamin E be of some help for preventing "in-stent restenosis"? Is it worth trying? Thanks!
if it is not ucc or high alt it is inflammation due to metabloic disease (if you are overweight this is for sure).
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