The issue of restenosis with DES is the reference in the post, and there is evidence dual therapy helps reduce restenosis with DES...
mechanism is not known, but the mechanism of action, etiology, differs between the two anti-platelet medications.
"Conclusions In this trial regarding CHARMISMA study, there was a suggestion of benefit with clopidogrel treatment in patients with symptomatic atherothrombosis and a suggestion of harm in patients with multiple risk factors.