clopidogrel and ppi interaction

I tried to copy and paste the second article you referred ot "Cardiologists shocked by a new FDA alert on clopidogral-ppi interaction," but was unable to access it. Could you tell us what it says? (Thanks.

FDA is alerting the public to new safety information concerning an interaction between clopidogrel (Plavix), an anti-clotting medication, and omeprazole (Prilosec/Prilosec OTC), a proton pump inhibitor (PPI) used to reduce stomach acid. New data show that when clopidogrel and omeprazole are taken together, the effectiveness of clopidogrel is reduced.

t take plavix in the morning and in the evening take lopressor 50mg and lipitor 80mg. I had been at least 4 hours since i took these two medication lopressor and lipitor. Is it ok to take zantac 150mg for heart burn .

I've followed this research, and from what I've learned the drug interaction of Plavix and PPI's (proton pump inhibitors) is not not that strong. I doubted the report from the start as I took Plavix and PPI's and my blood was as thin as tea, I bruised very, very easily, and the blood tests to determine my clotting factor wasn't changed by taking the two drugs.

To date there have been no reports of an important interaction in humans between warfarin and clopidogrel. Nonetheless, because warfarin increases the risk of bleeding, blood tests to measure the degree to which the blood is anti-coagulated or thinned (prothrombin time; INR) may be ordered to assess the degree of blood-thinning when warfarin and clopidogrel are used together.

The same group of investigators also studied iron absorption in 14 patients fed an iron-loaded meal before and after PPI therapy for one week. PPI therapy was associated with a 51% reduction in area under the serum iron concentration-time curve (AUC 0 to 4 hours); a 55% reduction in maximum increase of serum iron following ingestion of iron-loaded meal; and a 46% reduction in percent recovery of administered iron at peak serum iron concentration.

ve eight stents and always was given a handful of Clopidogrel (Plavix) during the prep time before the surgery, and a couple of aspirins. They want the blood as thin as possible during the procedure to reduce the risk of stroke or arterial obstructions, obviously. I'd not be concerned and take the medication as asked. Best wishes with the procedure, keep us informed.

Atorvastatin is supposed to be one of the two most effective statins in lowing cholesterol so you are on a good one. Bioavailability is how well a med is absorbed and used by the body and bioavailability varies among the statins. It's actually a desired thing. The liver is the target organ so if it is slowed down in the liver (where this happens), it's in the target organ. But honestly, that is hard for me to understand.

Hi, I was on gabapentin and was on a PPI called Prilosec. If in doubt u should talk to ur Dr or pharmacist as they r better suited to inform u on drug interactions. They may inform u to take at diff times and what to avoid to help the meds aid u..... Did u develop the reflux once u started with the gabapentin or did u have it b4?

I would just keep to the medications prescribed and eat a healthy diet. The Clopidogrel is important for the Stent and the drug coating on the stent will help to inhibit the formation of scar tissue.

I am currently taking plavix, 81mg aspirin AND coumadin on a daily basis. I had a stent put in in July 2008 and triple by pass in 2006. I'm 64 and had my first MI at 33. My father died of an MI at 46, my EF is under 30%. My EP (at one hospital) just suggested I eliminate the plavix while my CHF specialist (at a nearby major research university) said I would be on plavix for a "long time" (forever?).

I have been on Coumadin for 18 years due to Lupus Anticoagulant (Antiphospholipid Syndrome) and several DVTs. In 2005 had MI with occlusion of the LAD artery and had drug stent inserted and I am still on plavix. My doc has debated when to take me off the Plavix safely....what are the recent studies about this dilemma? thanks so much!

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after a stent inplant how long must clopidogrel-winthrop be taken my heart attack was caused by cholestral which now a 3

In the mean time you could try some hot water, and/or baking soda to see if it is indigestion. When I was pregnant and could not take much I tried the hot water and baking soda and it did help. If you burp you pretty much know it is gas. If it is really bad perhaps you should call 911.

Which is better anticoagulnt from rivaroxaban and clopidogrel for stroke prevention.My grandmother had stroke 6 years ago and she has atrial fibrilation.So far she used clopidogrel as treatment but her new doctor perscribed medication with rivaroxaban (but it is far more expensive) ?

s heart valve and a pacemaker and they were taking the medication clopidogrel for 7 years and then stopped taking it for a few months, could there be any ramifications?

i am 38 years old now , i developed gerd in my twenties i have been on ppi for like 10 years and they completely controlled my symptoms all this period i was on pantoprazole 40 mg daily and every time i try to dc for a month or two the gerd settles in and heart burn starts in episodes about 2-4 times daily so i eventually returned to ppi , every while i try to lower the dose to 20 mg for a period till i get the feeling of a slight discomfort so i return to the 40 mg dose again i tried h2

Well before any decision is made for something like Warfarin, you should have your INR (clotting factor) tested. An INR of 1 is how long normal blood takes to clot. An INR of 2 means it take twice as long and so it goes on. Aspirin and Clopidogrel (plavix) I believe attack the clotting mechanisms in different ways. Personally I don't think they know the long term outcomes.

My problem is that i get these times that either i go to sleep and the doctors not been able to wake me up the next morn and im unresponsive to pain and verbal stimuli ie scoring gcs of 3. My observations are ok but i can be bought round with oxygen too. Has anyone had this? Ive seen one instance but in canada where its been reported. My seizures increased so they have upped clobazam to 3pmg a day Im just worried as live on my own.

s like if I want some Clopidogrel (another form of anti platelet med) I could ask for either Clopidogrel or Plavix, Plavix is the brand name the drug company trades the medication under.

Clopidogrel and ppi interaction

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