In patients who have developed localized contact sensitization to <span style = 'background-color: #dae8f4'>clonidine</span>
film, substitution of oral clonidine
hydrochloride therapy may be associated with the development of a generalized skin rash.
In patients who develop an allergic reaction from clonidine
film that extends beyond the local patch site (such as generalized skin rash, urticaria, or angioedema), oral clonidine
hydrochloride substitution may elicit a similar reaction.