Clonidine is a medication that is generally used to ease the symptoms of
opioid withdrawal. To be honest, though,
clonidine is only slightly helpful, and comes with its own side effects like sedation, dry mouth, fatigue, and dizziness. Opioid withdrawal can be very severe in people taking high-potency opioids like heroin, fentanyl, or oxycodone-- so severe that people generally cannot even walk during the first week, and the legs are kicking uncontrollably.