New Onset or Worsening Renal Impairment
Tenofovir is principally eliminated by the kidney.
Renal impairment, including cases of
acute renal failure and Fanconi syndrome (renal tubular injury with severe hypophosphatemia), has been reported with the use of VIREAD [See ADVERSE REACTIONS].
It is recommended that creatinine clearance be calculated in all patients prior to initiating therapy and as clinically appropriate during therapy with VIREAD.