Theres no otc pain relievers that Im aware of that have negative
interaction with
clonidine, and yes you can take immodium. I take
clonidine still to this day for my blood pressure and I use naproxen, aspirin,tylenol etc. and I was taking immodium during my detox while on clonidine. If you want to be safe go to drugs.com and look up clonidine and it will tell you all the possible interactions it can have. As far as I know there shouldnt be anything to worry about.