Kraus and associates compared the effectiveness of citalopram
In depressed patients, Hospital <span style = 'background-color: #dae8f4'>anxiety</span> and
Depression Scale (HADS) scores had increased significan
tly during antiviral treatment but decreased significan
tly within 4 weeks after initiation of SSRI treatment. Placebo patients showed no significan
t improvement in HADS scores.
The study was terminated prematurely after a planned interim analysis showed a significan
t advantage for SSRI treatment.