cellcept and pml

I am considering just staying on Prednizone for a little while longer and getting pregnant, and then going on cellcept. I have been on cellcept one week tomorrow, and think it would not be too late to discontinue (after talking to my doctor again) since I am also still on 40mg of prednizone every day. Do you have any opinions about cellcept and pregnancy?

I see ou wrote this a while back but I am hoping you are still here and will see my question. I am supposed to start taking Cellcept for Lupus and I can't find anyone who can tell me anything about how they did on it. Are you there? Did you have any side effects while on it?

I take Cellcept for 2 and a half year. How long will last taking of this medicine because my hair and stomack can't stand it any more?

bad taste in mouth, aches and pains with muscles and joints, diarrhea, and headache. No fever or nausea. Am I just complaining or should I take more seriously. I had blood drawn today. My next appointment with my transplant team is june 15.

Our doctor was part of the testing of both drugs, and said that strangely, the incidence of PML is much higher in Rheumatoid Arthritis patients on Rituximab than on the MS population on Rituximab. The incidence of PML was almost 0% in the MS group. The same company that makes Rituxan has another monoclonal anti-body drug beginning testing, for MS. Hopefully insurance will then cover that one.

I take Cellcept and only Cellcept. I've been on it now for over a month. My MS doctor prescribed it for my PPMS since there's really no treatment for PPMS. I haven't had any side effects from it. When I first started on it, I did get some headaches but nothing I couldn't handle. In my case, I take it to hopefully slow down the progression of my particular form of this disease. Let me know if I can answer any questions.

Till two weeks back she was on PanGraaf 4mg, Wysolone (steroid) 15mg and CellCept 1000 mg a day. At that time (i.e. two weeks back) her blood result showed that her TLC has slipped to below normal (which is minimum 4) and was showing as 2.8. Her Haemoglobin seems to have settled around 11.2. All other results including Blood, LFT, Creatine etc show normal. Doctor reduced her CellCept to 500 mg (from 1000mg) and increased PanGraaf to 5 mg (from 4mg) and Wysolone (steroid) to 12.5mg (from 15 mg).

that affected my legs so my Dr. just prescribed Cellcept. I filled the prescription yesterday and was scared to death after reading the literature on it. What is PPMS? I will be interested in seeing if anyone has used this medication too. Sunnyb.

After a upper respiratory infection last month I have been having someone more weaknesses and even a slight breathing problem at times, so he wants to put me on Cellcept. The problem is Cellcept can cause Lymphoma and other side effects and infection risk,. I want to get off Prednisone due to weight gain and creeping up hypertension and the Mestinin digestive problems are a real pain.

5mg and tenofovir 300mg) and prograf, cellcept wysolone etc. Two months back entacavir was withdrawn and I am now treated with tenofovir, prograf(6mg), cellcept(1000mg) and Magnesium suppliment. Almost at the same time( 2months back) I suffered from maleria also. Since then SGOT and SGPT are gradually rising from normal level, and they are now 69 and 46 level( normal range is 4) and rose to 3.2 almost one month back but it goes down to 2.3 now. What could be reason?

Next month will be my 8th infusion. It does take about 6 months to get the full effects of Tysabri. I was very concerned about PML & have followed it much. The earliest PML happened was at 8 months for a person using it for Crohns, before it was pulled from the market in 2005. The latest case was after 26 infusions in 2008. I thought I will just start it & not worry about it until I get to that 8 month and decide then.

I have been diagnosed with CIDP, and have gone through the "normal" protocol.. prednisone, IvIG, plasmapheresis, with no real help. My neurologist now suggests therapy with cytoxan or cellcept. He is "saving" the stem cell/bone marrow transplant as a last resort. I have read all of the info on both drugs and the risk/benefit for each.

I have JUST started Tecfidera, and I too am a bit creeped out by the tales of PML, (and I was not tested for JC, but I guess they aren't doing that just yet with Tec.)but I will be insisting (if necessary) that I be monitored to MY satisfaction, and will switch to something else if it doesn't work, or my numbers go too low, or if I just am no longer comfortable with how close I am to a limit.

But the neuro also talked about Natiluzamab (tysabri) and the PML problems associated with it. The take aways were: PML occurs with other drugs/diseases too, but doesn't occur spontaneously. People with JC Virus negatives NEVER develop PML according to the stats. Most interesting to me was the idea that that European incidence rate of PML is hypothesized to be significantly greater because of the cost constraints of health care.

htm) The risks and benefits of continuing treatment with Tysabri should be carefully considered in patients who are found to be anti-JCV antibody positive and have one or more of the other known risk factors for PML. Patients with all three known risk factors have an estimated risk of PML of 11/1,000 users. The risk factors are: The presence of anti-JCV antibodies. Longer duration of Tysabri treatment, especially beyond 2 years. Prior treatment with an immunosuppressant medication (e.g.

• Although the absolute risk for PML in patients treated with Tysabri cannot be precisely determined, the U.S. FDA and the company have released data suggesting that the risk increases with increasing time on therapy. • The company changed the label of Tysabri to indicate that the risk of PML is increased in patients who have been treated with an immunosuppressant (such as mitoxantrone, and less commonly, azathioprine and methotrexate) prior to receiving Tysabri.

I am on 5 mg of prednisone and cellcept as well. Can I ask why you stopped taking the cellcept? My Dr is trying to lower me off of the prednisone all together and just stay on the cellcept. I was on 10 mg of pred 4 weeks ago, down to 7.5 mg 2 weeks ago and just got reduced to 5 mg. My numbers are staying in great shape, but I am still holding steady on the cellcept. I have been battling AIH for a year and a half. Nothing has worked w/the prednisone accept for cellcept.

adding the cellcept would be to try and lower the prograf concurrently

1) exposure to JC virus 2 time on drug (longer than 2 years) 3) prior exposure to immunosuppression As of 10/2012 there have been a total of ~305 cased of PML to date and about ~108,300 patients exposed to Tysabri to date. Only 54 cases occurred during the 1st twelve infusions. Roughly 21% of the cases were fatal. Only ~20% were able to return to work after treatment. The current PML estimated risk stratification is as follows: Patient with JCV antibody NEGATIVE status: _<0.

In the majority of cases, the culprit lesion is limited to the posterior mitral leaflet (PML), which is treated with quadrangular resection of the prolapsing PML, annular plication of the corresponding segment of the annulus, and prosthetic annuloplasty.

"Genentech withdrew its psoriasis drug Raptiva from the market yesterday, citing the risk of developing progressive multifocal leukoencephalopathy (PML), a rare, often fatal brain infection. The drug will be phased out by June 8 of this year, according to a statement by the US Food and Drug Administration (FDA)." http://www.the-scientist.com/templates/trackable/display/blog.jsp?

These have all been coming and going every day along with a temp that just before taking my CellCept will be around 99.2 - 99.6. After taking my medication my temp drops to my normal 96.6 - 97.4 temp range. So I guess that means the CellCept is suppressing my immune system? LOL.

The equivocation comes from the occasional false negative of the JC blood test, so that the very rare person with PML and a negative result on the JC virus mostly likely actually has the virus which was not detected. There was some thinking that a Tysabri vacation could help prevent PML. I have not seen this evidence. Now - what I am about to talk about is not published and no one should act on it, but it is very interesting.

Right now my doc is tring Cellcept. The jury is still out. But I have been on steroids, Plaquenil, Arava, Methotrexate and now Cellcept.

I hate to ask my doctors the question of this taking my life and how soon. I am on prednisone that we are weaning off and Cellcept 3000 mg per day. It was considered in the mild to moderate stages, but the docs are not sure how this should be treated. no studies have been done on this and am kinda in limbo....

Cellcept and pml

Common Questions and Answers about Cellcept and pml

cellcept