Some meds cause release of histamine. Most common example is narcotics.
We may have an <span style = 'background-color: #dae8f4'>allergy</span> to
a med. I had blotchy hives on hands and
feet for years until I realized I was allergic to
NSAIDs - Non-Steroidal Anti-Inflammato
ry Drugs like ibuprofen, celebrex
, Naproxen. It is IMPOSSIBLE to
effectively scratch the palms and soles - the skin is to
Sensitive skin is irritated sometimes with abrasion from tight clothing.