Calcitriol kidney disease

Common Questions and Answers about Calcitriol kidney disease

dovonex

My dog was diagnosed with kidney disease last year. I switched his food and also started giving him a herbal tonic called Tripsy from PetWellbeing. Since he's been on it, its like I have my old dog back. Please don't give up hope just yet. Check out Tripsy and ask your vet about it as well. Good Luck! http://www.petwellbeing.
I have been taking 2400 mg. calcium citrate daily as well as .25 mcg. Calcitriol 4 times per day. I also take 100 mcg. Synthroid. My test results for February 23 were as follows: Serum Calcium: 8.3; Ionized Calcium: 1.05; Magnesium: 1.9; PTH: 14.6; T4: 1.2; TSH: 0.09. My test resuslts for March 23 were as follows: Serum Calcium: 10.1; Ionized Calcium: 1.27; Magnesium: 2.0; PTH: 2.5; T4: 1.2; TSH: 0.11.
Aluminum hydroxide (ALOH) is currently recommended by Board Certified Veterinary Internists at the University of Davis, veterinary hospital as the product of choice to use in pets to effectively bind and eliminate excess phosphorus from the body. It has effectively replaced Epikacin for this purpose. Epikacin, is an old Calcium based product, formerly used to bind excess phosphorus and help eliminate it from the body, in pets with kidney failure.
The calcitriol will help decrease the PTH and help prevent bone disease.
Chronic Kidney Disease is not reversible but is treatable. Initially dogs drink and urinate excessively. The urine produced is dilute so dogs become dehydrated and drink a lot to try to replace the lost fluids. No matter how much they drink; they are unable to maintain normal hydration. Advanced signs of Kidney Disease include weight loss, vomiting, depression and loss of appetite. Signs are not apparent until 80 percent of kidney function is already lost.
It is heartwrenching to hear what you are going through, particularly as it brings what happened to BB and our 'family' all back. I can tell you that kidney disease can fool you into thinking things are ok for a while, as there are good and bad days, but sadly the bad days become more common and eventually there are only bad days with no good ones. I would agree with what others have said, once a dog stops eating completely, the time is very close (probably two or three days at most).
25 HYDROXY VITAMIN D, reported a good reading,however the PTH test is elevated outside the range-5 times, why would a kidney specialist want to consider Vitamin D therapy, Rocaltrol(calcitriol), the drug used here in Australia?
It is used for chronic renal disease and renal osteodystrophy. Calcitriol is an active form of Vitamin D which is produced in the normal kidney. Diseased kidneys are unable to produce enough calcitriol to support electrolyte balances in the body, and to keep another hormone: parathyroid hormone in check. This process can lead to imbalances of calcium, phosphorus and other electrolytes.
It is designed specifically for dogs with kidney disease. Also, if you Google Canine Kidney failure, diets you will get a whole slew of links that give you easy to prepare recipes that you can cook for him at home that will help tremendously and might even buy him a considerable amount of time. I had a puppy in my rescue that had been turned in because his owners couldn't bring themselves to put him down, but they couldn't afford to care for him any longer.
I'm a big fan of vitamin D. Obviously, everyone should be taking a daily dose of vitamin D. Where we see an inexpensive way for all people to maintain their health, Big Pharma sees only dollar signs. At the end of last month, biopharmaceutical company Rockwell Medical announced that it had scored an Abbreviated New Drug Application for injectable vitamin D (dubbed Calcitriol) for people with end-stage renal disease who are undergoing hemodialysis.
“Acute” kidney disease occurs suddenly, is rare in dogs, and with prompt treatment is generally reversible. Long-term “chronic” kidney disease is also called chronic renal disease and is the most common form in dogs. It is usually the result of slow age-related deterioration of the kidneys. SIGNS Initially dogs drink and urinate excessively. The urine produced is dilute so dogs become dehydrated and drink a lot to try to replace the lost fluids.
Calcitriol is a natural form of Vitamin D that was formerly used for human dialysis patients to restore kidney function. Calcitriol is currently available for dogs and cats in kidney failure and veterinarians order it through various compounding pharmacies. Calcitriol is compounded specifically for each pet according to their body weight and BUN-Creatinine levels. It is given to pets as a capsule by mouth once a day.
Fluid therapy is the single most important factor in the treatment of kidney disease. The kidneys normally function to maintain fluid levels by concentrating the urine. With kidney disease, excess fluids are lost into the urine so dehydration is a major problem. Good nutrition is also critical. The goal is to decrease the workload on the kidneys by decreasing the amount of waste the kidneys must eliminate. Excess dietary protein, phosphorus, calcium and salt create a lot of waste.
Hi **, First let me ask if you've been diagnosed with a kidney disease. I'm experiencing the same issues. The thing is that I'm in stage 4 CKD with secondary hyperparathyroidism. The burping I'm having is a result of the hyperparathyroidism as well as the joint pain. I'm currently taking calcitriol and 800 IU of Vitamin D daily. I noticed when I ran out of the Vitamin D for a few days it felt like someone was trying to rip my hip out of place. It was very painful.
These cells express CYP27B1, the gene encoding for the enzyme responsible for the synthesis of the vitamin-D hormonally active metabolite, calcitriol. Treatment with vitamin-D(3) resulted in calcitriol production and induction of calcitriol target gene CYP24A1, indicating that these cells contain the full machinery for vitamin-D metabolism and activity. Notably, treatment with calcitriol resulted in HCV inhibition.
That said there are some options to maybe help decrease your rates before trying to conceive. Life Options has some online type free kidney disease classes that might help you also find ways to bring it down. If you pm next week with your e-mail address.... this one is crazy I will try to dig up the articles I found to help me and e-mail them to you! The one BIG thing I did read was decreasing the amount of protein in your diet, since this is one of the hardest on the kidneys! Esp.
Fluids given daily at home under the skin (Sub-Q) are vital to flush toxins from the body with kidney disease. The fluid of choice is 0.9% NaCl (sodium chloride) We do not recommend Lactated Ringers solution as it contains calcium and phosphorus, both of which are generally already elevated in dogs with failing kidneys. A home made diet is quite helpful. Many vets prescribe Hills K/D Diet. Hills K/D Diets are ok however they not very palatable or tasty and many dogs will not eat K/D.
Endocrinologist blew me off and said I had kidney failure and probably needed more vitamin D. I have one kidney so that startled me. That and being angry over being blown off led me to pay out of pocket for a kidney specialist and CT. Verdict : see an endocrinologist about parathyroid tumor/nothing wrong with kidney to cause declining function.
“Acute” kidney disease occurs suddenly, is much less common than chronic kidney disease in pets, and with prompt treatment is generally reversible. Long-term “chronic” kidney disease referred to as chronic renal disease is the most common form in dogs and cats. It is usually the result of slow age-related deterioration of the kidneys. Signs of Pet Kidney Disease Initially dogs and cats drink and urinate excessively.
can you have medullary sponge kidney if ct scan doesnt show cysts? i have extensive bilateral nephrocalcinosis, never had a kidney stone. i sometimes have hypokalemia and almost always have leukocytes in urine. first nephrologist told me ct scan showed it was not msk and we had to get to the bottom of it to prevent further kidney damaged. she couldnt figure out what it was before i moved 500 miles away.
Treatment with vitamin D(3) resulted in calcitriol production and induction of calcitriol target gene CYP24A1, indicating that these cells contain the full machinery for vitamin D metabolism and activity. Notably, treatment with calcitriol resulted in HCV inhibition. Collectively, these findings suggest that vitamin D(3) has an antiviral activity which is mediated by its active metabolite.
For example hypertension (high blood pressure) may be a cause or an effect of kidney disease. That should be assessed and medicated as required. Some renal disease patients feel nauseous due to stomach irritation or ulceration. Often a coating agent, sucralfate, is used along with antacids such as famotidine (Pepcid) ranitidine (Zantac) and others to address this. There are also other treatable issues that arise with chronic kidney disease which you should be made aware of by your doctor.
Other causes of kidney disease include bacterial and viral infections, nutritional factors, immune system defects, toxins, and inherited breed disorders. “Acute” kidney disease occurs suddenly, is much less common than chronic kidney disease in pets, and with prompt treatment is generally reversible. Long-term “chronic” kidney disease referred to as chronic renal disease is the most common form in dogs and cats. It is usually the result of slow age-related deterioration of the kidneys.
9 cal and 45 PTH) So I was told I don't have Hyperparathyroidism. This was shocking to me because I have 11 kidney stones currently, (calcium Oxalate no less) and have passed prob 10-15 stones since I was 17 years old (Now I am 28). I have ever single symptom listed on http://parathyroid.com including a racing pulse and was sent to see a Heart doctor because of abnormal EKG and arrhythmias. They did all kinds of test (Nuculear stress test, 24 hr monitor etc...
An excess of vitamin D causes abnormally high blood concentrations of calcium (hypercalcemia), which can cause overcalcification of the bones, soft tissues, heart and kidneys. It can also damage the kidney and produce kidney stones Please follow the advice, diagnosis, and treatment recommended by your medical provider. If you don't feel comfortable with that advice get a second opinion from another medical professional .
Vitamin D supplements should be avoided or taken with close physician supervision by people with kidney disease, hypercalcemia, sarcoidosis, or hypoparathyroidism. Vitamin D may interfere with “cardiac glycosides” medications (digitoxin or digoxin, for example). There is a small increase in the risk of kidney stones. Other factors, including diet, medical history, and possible side effects should be balanced against the limitedevidence of benefit.
“Low levels of 1,25 di OH Vitamin D can be seen in kidney disease and are one of the earliest changes to occur in persons with early kidney failure. “High levels of 1,25 di OH Vitamin D may occur when there is excess parathryoid hormone or when there are diseases, such as sarcoidosis or some lymphomas, that can make 1,25 di OH Vitamin D outside of the kidneys.
Medullary cystic kidney disease Renal tubular acidosis Distal renal tubular acidosis/type 1 Medullary sponge kidney disease Hereditary, Familial, Genetic Disorders: Hyperparathyroidism, neonatal, hereditary Familial hypocalciuric hypercalcemia Gittleman's syndrome Bartter's syndrome Anatomic, Foreign Body, Structural Disorders: Kidney stone/urolithiasis/nephrolithias Functional, Physiologic Variant Disorders: Bed rest, prolonged High calcium diet Vegetative, Autonomic, Endocrine Disorders:
I was taking massive doses of calcium upon release, 16 pills a day (at 500 mg a pill), in addition to magnesium, vitamin D (calcitriol) and hydrochlorothiazide. This combination of drugs can lower your potassium, so be sure to check that as well at some point. I think the test is part of the normal "panel" they do. Gradually, in consultation with the doctor and after many blood tests, I have decreased the dosage. My parathyroids are kicking in again.
MedHelp Health Answers