My script just said to take 300 mg 2 X a day. Thank God I didn't do that. Dumb Drs.
A nurse told me to take 150
mg first thing in the morning. Then take the other 150
mg by 2 or 3 pm. Wellbutrin is supposed to be activating so you don't want to take it at night. I found that it did not interfere with my sleep at all.
I did feel irritated too. But then a couple of weeks in, I started to feel so sad. The sadness was worse than any sad I had ever felt.