Buprenorphine treatment of refractory depression
Common Questions and Answers about Buprenorphine treatment of refractory depression
suboxone
to the effects it creates, and that ceiling has effects about equal to the effects of taking oxycodone 60 mg. If you give buprenorphine to a person who is taking nigh doses of oxycodone, you usually cause withdrawal. I am surprised that you were able to add a buprenorphine patch, while taking oxycodone, without getting withdrawal symptoms.
Depression is very common during opioid withdrawal, and is the worst symptoms for most people.
It is used in cases of extreme treatment refractory depression. More of interest including to yourself is a procedure called trans cranial magnetic stimulation which appears to have less long term side effects than ECT and is effective.
You will find my opinion here and there, so my comments will be more educational than suggestive.
Is it an Opiate? It depends on the definition of 'opiate'; it is not structurally related to opium, the definition of opiates that some people use-- for example heroin, codeine, and morphine are 'opiates' by that definition, but fentanyl and buprenorphine are not.
Suboxone is the brand name for a medication consisting of buprenorphine and naloxone. Buprenorphine is a thebaine derivative with powerful analgesia approximately 20-40x more potent than morphine. Buprenorphine is a partial agonist and antagonist of the opioid receptors in the central nervous system which means that when its molecule binds to a receptor, it will transduce only a partial response in contrast to a full agonist such as morphine.
//www.adaa.org/finding-help/treatment/clinical-trials/Riluzole-Medication-Study-for-Treatment-Refractory-OCD
3. An Open-label trial of Riluzole, a Glutamate Antagonist, in Children with Treatment-resistant Obsessive-compulsive Disorder, Grant P, Lougee L, Hirschtritt M, Swedo SE, J Child Adolesc Psychopharmacol. 2007 Dec;17(6):761-7. doi: 10.1089/cap.2007.0021.
In the United States ECT is used when all known anti-depressents have failed to help a person and they have treatment refractory depression or if the person is suicidal and anti-depressents don't help. In other countries it may be used beyond that point but basically should be considered an option after a person cannot be treated with anti-depressents. For some more information on anti-depressents google "Depression Central".
I'm sorry not a lot of people responded to your post. I do 95% agree with ILADVOCATE. The info he gave you is pretty much on target.
I wish I could tell you that this type of Depression would just go away like the flu or cold, but unfortunatly that is not usually the case. The only 5% left that I was talking about is HOPE. You never know what new treatments are around the corner and that means hope for a cure or maybe even a treatment so good that it eliminates 100% of our symptoms.
The doctors do not like her CA125 level and will meet with us to discuss alternate and additional chemo
It should ONLY be considered by the 10 to 15 percent of us long term sufferers that have absolutly exhausted all other forms of therapy and medication to treat the kind of Refractory depression that simply doesn't respond to anything else.
NEVER take Tramadol without first consulting your Psychiatrist. Like I said, as with meds like Xanax it can be addictive for some people and should be treated with caution.
Understand that I realize this is not a standard treatment.
A quarter of one tablet of Suboxone contains 2 mg of buprenorphine, or 2000 MICROGRAMS!! So any dose of Suboxone is 'overkill'-- even a sliver of a tablet contains an amount of buprenorphine that is quite high, and possibly over the 'ceiling dose'. Stopping 16 mg Suboxone is like abruptly stopping 30 mg of methadone... and stopping 2 mg of Suboxone is like stopping 30 mg of methadone!
TMS is generally used for treatment refractory depression but it has been used on treatment refractory schizophrenia as before my current recovery (and before TMS was clinically approved) I considered being a participant in that study. Before you would even consider that though you should have your psychiatrist try a combination of all available mood stabilizers and antipsychotics depending what they think is going on.
I believe they are researching efficacy but since its FDA approved trans cranial magnetic stimulation has shown results that are conclusive for treatment refractory depression. This article might be of help:
http://www.nami.org/Content/ContentGroups/Helpline1/Transcranial_Magnetic_Stimulation_(rTMS).htm.
First thing...stop the Chantix. Yes, in many people even those with no history of major depression Chantix is proven to have the potential to cause depression.
There are better ways to stop smoking than to alter your brain chemistry.
s of scientific studies that prove without a doubt that some forms of refractory depression are a direct cause of biological and neurological defects in how the brain processes chemicals that regulate mood and anxiety. This is not scince fiction, but very real.
Traditional antidepressants can in some cases help alot, but they do not address all of the complex factors in the brain that cause this kind of depression.
As far as I've been told there are 5 types of depression, one of them being refractory depresion which means hard to treat. It takes time to find the right med too. ECT isn't as bad as it used to be, it's far more effective and painless, as well the side effects are far less. I've contemplated it myself. I'm on a mood stabilizer, and I'm still not feeling 100%, but i was warned that depression may never fully lift.
The recent approval of office-based treatment for opioid addiction using buprenorphine expands treatment options for opioid addiction. However, the utility of this drug in controlling chronic pain in those suffering with chemical dependencies, although intuitively elegant, has yet to be fully explored. Buprenorphine’s clinical efficacy results from its unique molecular structure: it is a partial μ opioid agonist and a weak antagonist.
As for safety, Buprenorphine was a favorite for control of pain during labor until the epidural became more commonly used; I have a number of papers from studies of the use of Suboxone or buprenorphine during pregnancy, breast-feeding, and delivery, and in all of them buprenorphine comes out looking better than agonists such as methadone.
As far as comments like 'Sub caused me to have more pain'-- that is simply silly.
I have been receiving monthly counciling and medication reviews for over 16 years, and have to take three different medications just to control my Cronic Refractory Depression and I still have a lot of creative ideas that are far from rigid in thought or application.
In fact, besides feeling like absolute **** much of the time due to my cronic illness, I am still pretty much the same person I was before being body slamed with this disease.
As far as fear of intamacy...... No way.
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