found (1991) that URINARY URIC ACID CLEARANCE DECREASES IN PROPORTION TO INCREASES
IN INSULIN RESISTANCE
in normal volunteers, leading to an increase
in the
serum uric acid concentration. The mechanism explaining the observed association is unclear. On the one hand, there are mechanisms implying DECREASED RENAL EXCRETION OF URIC ACID IN THE PRESENCE OF HYPERINSULINEMIA, including increased levels of ketoacids and increased sodium reabsorption with the elevation of uric acid (Modan et al. 1987).